Thromboxane B2-d9

Thromboxane B2-d9 (TXB2-d9) is intended for use as an internal standard for the quantification of TXB2 (Cay-19030) by GC- or LC-MS. TXB2 is a non-enzymatically derived, stable, inactive metabolite of TXA2, which is highly unstable. Serum levels of TXB2 positively correlate with platelet COX-1 activation. Urinary levels of TXB2 reflect intrarenal TXA2 synthesis, while its metabolites, 11-dehydro TXB2 (Cay-19500) and 2,3-dinor TXB2 (Cay-19510), reflect systemic TXA2 secretion.Formal Name: (Z)-7-((2R,3S,4S)-4,6-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl-5,5,6,6,7,7,8,8,8-d9)tetrahydro-2H-pyran-3-yl)hept-5-enoic acid. Synonyms: TXB2-d9. Molecular Formula: C20H25D9O6. Formula Weight: 379.5. Purity: >99% deuterated forms (d1-d9). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: >50 mg/ml, DMSO: >25 mg/ml, Ethanol: >100 mg/ml, Methyl Acetate: 10 mg/ml, PBS (pH 7.2): >100 µg/ml. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)CC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])OC(O)C1. InChi Code: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1/i1D3,2D2,3D2,6D2. InChi Key: XNRNNGPBEPRNAR-DFRAMZSTSA-N.