tetranor-PGEM-d6

tetranor-PGEM-d6
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay314840-25 25 µg -

5 - 10 business days*

274.00€
Cay314840-50 50 µg -

5 - 10 business days*

520.00€
Cay314840-100 100 µg -

5 - 10 business days*

985.00€
 
Tetranor prostaglandin E metabolite-d6 (tetranor-PGEM-d6) contains six deuterium atoms at the 13,... more
Product information "tetranor-PGEM-d6"
Tetranor prostaglandin E metabolite-d6 (tetranor-PGEM-d6) contains six deuterium atoms at the 13, 13, 14, 14, 15, and 15 positions. It is intended for use as an internal standard for the quantification of tetranor PGEM by GC- or LC-mass spectrometry. Tetranor PGEM-d6 is the major urinary metabolite of PGE1 and PGE2. It is used as a urinary marker of PGE2 biosynthesis, and to monitor metabolism after infusion or injection of PGE1 as a pharmaceutical. Normal healthy males excrete 16-30 µg of tetranor PGEM over a 24-hour period. Females excrete less by about a factor of three. Following oral administration (4 x 50 mg/24 hours) of the COX inhibitor, indomethacin, urinary levels of tetranor PGEM decrease by 75-98% indicating the almost complete loss of PGE2 biosynthesis. Formal Name: 9,15-dioxo-11alpha-hydroxy-13,14-dihydro-2,3,4,5-tetranor-prostan-13,13,14,14,15,15-d6-1,20-dioic acid. CAS Number: 1240398-16-6. Synonyms: tetranor-Prostaglandin E Metabolite-d6. Molecular Formula: C16H18D6O7. Formula Weight: 334.4. Purity: >99% deuterated forms (may contain d4-d8). Formulation: A solution in methyl acetate. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: Not Stable, PBS (pH 7.2): 1 mg/ml. SMILES: O=C1[C@H](CCC(O)=O)[C@@H](CCC(CC([2H])([2H])C([2H])([2H])C([2H])([2H])C(O)=O)=O)[C@H](O)C1. InChi Code: InChI=1S/C16H24O7/c17-10(3-1-2-4-15(20)21)5-6-11-12(7-8-16(22)23)14(19)9-13(11)18/h11-13,18H,1-9H2,(H,20,21)(H,22,23)/t11-,12-,13-/m1/s1/i1D2,2D2,4D2. InChi Key: ZJAZCYLYLVCSNH-VFBFAAMGSA-N.
Keywords: tetranor-Prostaglandin E Metabolite-d6, 9,15-dioxo-11alpha-hydroxy-13,14-dihydro-2,3,4,5-tetranor-prostan-13,13,14,14,15,15-d6-1,20-dioic acid
Supplier: Cayman Chemical
Supplier-Nr: 314840

Properties

Application: Standard
MW: 334.4 D
Formula: C16H18D6O7
Purity: >99% deuterated forms (may contain d4-d8)
Format: Solution

Database Information

CAS : 1240398-16-6| Find alternatives

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -80°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: EUH066, H225, H319, H336
P Phrases: , P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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