Sulprostone

Sulprostone is a metabolism resistant synthetic analog of PGE2. It is a selective agonist for EP3 receptors with a Ki value of 0.35 nM at the human recombinant EP3-III receptor and an IC50 of 0.01 µM for the inhibition of PGE2 binding. Sulprostone is a potent stimulator of uterine smooth muscle contractions with high abortifacient activity. Formal Name: N-(methylsulfonyl)-9-oxo-11alpha,15R-dihydroxy-16-phenoxy-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-amide. CAS Number: 60325-46-4. Molecular Formula: C23H31NO7S. Formula Weight: 465.6. Purity: >98%. Formulation: A solution in methyl acetate. Solubility: DMF: >10 mg/ml, DMSO: >14 mg/ml, Ethanol: >25 mg/ml, PBS pH 7.2: >4 mg/ml. lambdamax: 220, 270 nm. SMILES: O=C1[C@H](C/C=C\CCCC(NS(=O)(C)=O)=O)[C@@H](/C=C/[C@@H](O)COC2=CC=CC=C2)[C@H](O)C1. InChi Code: InChI=1S/C23H31NO7S/c1-32(29,30)24-23(28)12-8-3-2-7-11-19-20(22(27)15-21(19)26)14-13-17(25)16-31-18-9-5-4-6-10-18/h2,4-7,9-10,13-14,17,19-20,22,25,27H,3,8,11-12,15-16H2,1H3,(H,24,28)/b7-2-,14-13+/t17-,19-,20-,22-/m1/s1. InChi Key: UQZVCDCIMBLVNR-TWYODKAFSA-N.