Succinobucol

Succinobucol is a metabolically stable derivative of probucol (Cay-15043) with diverse biological activities. It inhibits hydrogen peroxide-induced oxidation of the redox-sensitive dye H2DCF in human pulmonary artery endothelial cells (HPAECs) and U937 cells when used at concentrations of 5 and 10 µM. Succinobucol (0.3-10 µM) reduces LPS-induced production of IL-6, IL-1beta, and TNF-alpha in peripheral blood mononuclear cells (PBMCs). It suppresses TNF-alpha-induced vascular cell adhesion molecule 1 (VCAM-1) promoter reporter gene expression in human aortic endothelial cells. Succinobucol (50 and 100 mg/kg) lowers plasma LDL levels and increases HDL levels in hypercholesterolemic cynomolgus monkeys. It also inhibits the formation of aortic atherosclerotic plaques in ApoE-/- or Ldlr-/- mice.Formal Name: butanedioic acid, 1-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenyl] ester. CAS Number: 216167-82-7. Synonyms: AGI-1067, Probucol Monosuccinate. Molecular Formula: C35H52O5S2. Formula Weight: 616.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. SMILES: CC(C)(C)C1=CC(SC(C)(C)SC2=CC(C(C)(C)C)=C(OC(CCC(O)=O)=O)C(C(C)(C)C)=C2)=CC(C(C)(C)C)=C1O. InChi Code: InChI=1S/C35H52O5S2/c1-31(2,3)23-17-21(18-24(29(23)39)32(4,5)6)41-35(13,14)42-22-19-25(33(7,8)9)30(26(20-22)34(10,11)12)40-28(38)16-15-27(36)37/h17-20,39H,15-16H2,1-14H3,(H,36,37). InChi Key: RKSMVPNZHBRNNS-UHFFFAOYSA-N.