Sphingosine-1-phosphate (d18:1)

Sphingosine-1-phosphate (d18:1)
Lipid-based Drug Delivery Tools
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay62570-1 1 mg -

6 - 10 business days*

100.00€
Cay62570-5 5 mg -

6 - 10 business days*

369.00€
Cay62570-10 10 mg -

6 - 10 business days*

586.00€
Cay62570-25 25 mg -

6 - 10 business days*

1,171.00€
 
Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine... more
Product information "Sphingosine-1-phosphate (d18:1)"
Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors. It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC50s = 8 and 11 nM, respectively). Intra- and extracellular levels of S1P vary spatially allowing it to function as an autocrine or paracrine factor, respectively, and dysregulation of S1P levels are associated with various disease states, such as inflammation and autoimmunity. S1P has a wide variety of effects, including an involvement in cell growth, angiogenesis, immunity, and neuroprotection.Formal Name: 2S-amino-4E-octadecene-1,3R-diol 1-(dihydrogen phosphate). CAS Number: 26993-30-6. Synonyms: S1P (d18:1), Sphingosine-1-Phosphoric Acid. Molecular Formula: C18H38NO5P. Formula Weight: 379.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: .3 M NaOH: 4 mg/ml, DMF: <50 µg/ml, DMSO: <50 µg/ml, PBS pH 7.2: <50 µg/ml. SMILES: CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(O)(O)=O. InChi Code: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1. InChi Key: DUYSYHSSBDVJSM-KRWOKUGFSA-N.
Keywords: S1P (d18:1), Sphingosine-1-Phosphoric Acid, 2S-amino-4E-octadecene-1,3R-diol 1-(dihydrogen phosphate)
Supplier: Cayman Chemical
Supplier-Nr: 62570

Properties

Application: Bioactive lipid assays
MW: 379.5 D
Formula: C18H38NO5P
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 26993-30-6| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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