Resolvin E1-d4

Resolvin E1-d4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10009854-10 10 µg -

6 - 10 business days*

226.00€
Cay10009854-25 25 µg -

6 - 10 business days*

508.00€
 
Resolvin E1-d4 (RvE1-d4) is intended for use as an internal standard for the quantification of... more
Product information "Resolvin E1-d4"
Resolvin E1-d4 (RvE1-d4) is intended for use as an internal standard for the quantification of RvE1 (Cay-10007848) by GC- or LC-MS. RvE1 is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids. It is produced from eicosapentaenoic acid (EPA, Cay-90110, Cay-90110.1, Cay-21908) via an 18-HEPE epoxide intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA and 5-lipoxygenase (5-LO), by leukotriene A4 (LTA4) hydrolase in human polymorphonuclear (PMN) neutrophils. RvE1 activates chemokine-like receptor 1 (CMKLR1, EC50 = 0.137 nM in a reporter assay). RvE1 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A (Cay-21175). It increases survival and prevents decreases in colon length in a mouse model of TNBS-induced colitis when administered at a dose of 50 µg/kg. RvE1 (50 µg/kg) inhibits ovalbumin-induced increases in eosinophil and total cell numbers, as well as IL-13 and IgE levels in bronchoalveolar lavage fluid (BALF) in an ovalbumin-sensitized mouse model of asthma.Formal Name: 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic-6,7,14,15-d4 acid. Synonyms: RvE1-d4, 5S,12R,18R-trihydroxy-EPA-d4, 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-EPA-d4, 5,12,18R-triHEPE-d4. Molecular Formula: C20H26D4O5. Formula Weight: 354.5. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 0.05 mg/ml. lambdamax: 272 nm. SMILES: CC[C@@H](O)/C=C/C([2H])=C([2H])\C[C@@H](O)/C=C/C=C/C([2H])=C([2H])\[C@@H](O)CCCC(O)=O. InChi Code: InChI=1S/C20H30O5/c1-2-17(21)11-8-5-9-14-18(22)12-6-3-4-7-13-19(23)15-10-16-20(24)25/h3-9,11-13,17-19,21-23H,2,10,14-16H2,1H3,(H,24,25)/b4-3+,9-5-,11-8+,12-6+,13-7-/t17-,18+,19-/m1/s1/i5D,7D,9D,13D. InChi Key: AOPOCGPBAIARAV-VUOMCXAQSA-N.
Keywords: RvE1-d4, 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic-6,7,14,15-d4 acid
Supplier: Cayman Chemical
Supplier-Nr: 10009854

Properties

Application: GC-MS, LC-MS, internal standard
MW: 354.5 D
Formula: C20H26D4O5
Purity: >99% deuterated forms (d1-d4)
Format: Solution

Database Information

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319
P Phrases: P210, P233, P240, P241, P242, P243, P264, P280, P303+361+353, P305+351+338, P337+313, P370+378, P403+235, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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