Prostaglandin J2

Prostaglandin J2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay18500-500 500 µg -

6 - 10 business days*

115.00€
Cay18500-1 1 mg -

6 - 10 business days*

216.00€
Cay18500-5 5 mg -

6 - 10 business days*

899.00€
Cay18500-10 10 mg -

6 - 10 business days*

1,569.00€
 
Prostaglandin J2 (PGJ2) is a metabolite of PGD2 (Cay-12010) and an agonist of the prostaglandin... more
Product information "Prostaglandin J2"
Prostaglandin J2 (PGJ2) is a metabolite of PGD2 (Cay-12010) and an agonist of the prostaglandin D2 (PGD2) receptor subtypes DP1 and DP2/CRTH. It is formed from PGD2 by spontaneous dehydration. PGJ2 binds to DP1 and DP2/CRTH receptors (Kis = 0.9 and 6.6 nM, respectively) and either increases or inhibits the production of cAMP (EC50s = 1.2 and 13.1 nM, respectively, in HEK293 cells expressing the human receptors). PGJ2 is neurotoxic and induces apoptosis, oxidative stress, and the accumulation of ubiquitinated proteins in the brain. It promotes the cleavage of amyloid precursor protein (APP) by alpha- and beta-secretase in primary rat cerebral cortical neurons when used at a concentration of 10 µM. The levels of PGJ2 increase in the brain after stroke or traumatic brain injury (TBI) in rodents and it accumulates in the spinal cord of patients with sporadic amyotrophic lateral sclerosis (ALS).Formal Name: 11-oxo-15S-hydroxy-prosta-5Z,9,13E-trien-1-oic acid. CAS Number: 60203-57-8. Synonyms: PGJ2. Molecular Formula: C20H30O4. Formula Weight: 334.5. Purity: >95%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: >100 mg/mL, DMSO: >50 mg/mL, Ethanol: >75 mg/mL, PBS pH 7.2: >2.7 mg/mL. lambdamax: 216 nm. SMILES: CCCCC[C@H](O)/C=C/[C@H]([C@@H](C/C=C\CCCC(O)=O)C=C1)C1=O. InChi Code: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1. InChi Key: UQOQENZZLBSFKO-POPPZSFYSA-N.
Keywords: PGJ2, 11-oxo-15S-hydroxy-prosta-5Z,9,13E-trien-1-oic acid
Supplier: Cayman Chemical
Supplier-Nr: 18500

Properties

Application: Bioactive lipid assays
MW: 334.5 D
Formula: C20H30O4
Purity: >95%
Format: Solution

Database Information

CAS : 60203-57-8| Matching products

Handling & Safety

Storage: -80°C
Shipping: -80°C (International: -80°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H303, H319, H336
P Phrases: P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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