Prostaglandin F2alpha methyl ester

Prostaglandin F2alpha methyl ester
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay16011-500 500 µg -

6 - 10 business days*

32.00€
Cay16011-1 1 mg -

6 - 10 business days*

60.00€
Cay16011-5 5 mg -

6 - 10 business days*

250.00€
Cay16011-10 10 mg -

6 - 10 business days*

438.00€
 
Prostaglandin F2alpha methyl ester (PGF2alpha methyl ester) is an analog of PGF2alpha in which... more
Product information "Prostaglandin F2alpha methyl ester"
Prostaglandin F2alpha methyl ester (PGF2alpha methyl ester) is an analog of PGF2alpha in which the C-1 carboxyl group has been esterified as the methyl ester. PGF2alpha methyl ester was one of the first PG esters shown to have ocular hypotensive activity. This compound continues to be a standard by which other ocular hypotensive PG prodrugs are evaluated. The methyl ester is about 4-5 times more potent than the free acid, PGF2alpha. This difference is attributed to improved corneal penetration, and a depot effect of prolonged retention of the ester form of the compound in ocular tissue. A 2.5 µg dose of PGF2alpha-OMe applied to the eyes of cats results in a 6-8 mm Hg reduction in IOP. Formal Name: 9alpha,11alpha,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid, methyl ester. CAS Number: 33854-16-9. Synonyms: PGF2alpha methyl ester. Molecular Formula: C21H36O5. Formula Weight: 368.5. Purity: >98%. Formulation: A solution in methyl acetate. Solubility: DMF: 35 mg/ml, DMSO: 35 mg/ml, Ethanol: 50 mg/ml, Ethanol:PBS (pH 7.2) (1:4): 0.4 mg/ml. SMILES: CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(OC)=O. InChi Code: InChI=1S/C21H36O5/c1-3-4-7-10-16(22)13-14-18-17(19(23)15-20(18)24)11-8-5-6-9-12-21(25)26-2/h5,8,13-14,16-20,22-24H,3-4,6-7,9-12,15H2,1-2H3/b8-5-,14-13+/t16-,17+,18+,19-,20+/m0/s1. InChi Key: PJDMFGSFLLCCAO-NVRZHKMMSA-N.
Keywords: PGF2alpha methyl ester, 9alpha,11alpha,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid, methyl ester
Supplier: Cayman Chemical
Supplier-Nr: 16011

Properties

Application: Standard
MW: 368.5 D
Formula: C21H36O5
Purity: >98%
Format: Solution

Database Information

CAS : 33854-16-9| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: EUH066, H225, H319, H336, H360
P Phrases: , P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P308+313, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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