Prostaglandin F2alpha ethyl amide

Prostaglandin F2alpha ethyl amide (PGF2alpha-NEt) is an analog of PGF2alpha in which the C-1 carboxyl group has been modified to an N-ethyl amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that PG ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 µg/g corneal tissue/hr. PGF2alpha-NEt would be expected to show the typical intraocular effects of PGF2alpha free acid, but with the much slower hydrolysis pharmacokinetics of the PG N-amides.Formal Name: N-ethyl-9alpha,11alpha,15S-trihydroxy-prosta-5Z,13E-dien-1-amide. CAS Number: 54130-36-8. Synonyms: Dinoprost ethyl amide, PGF2alpha-NEt. Molecular Formula: C22H39NO4. Formula Weight: 381.6. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 33 mg/ml, DMSO: 16 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 300 µg/ml. SMILES: O[C@@H](CCCCC)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(N([H])CC)=O. InChi Code: InChI=1S/C22H39NO4/c1-3-5-8-11-17(24)14-15-19-18(20(25)16-21(19)26)12-9-6-7-10-13-22(27)23-4-2/h6,9,14-15,17-21,24-26H,3-5,7-8,10-13,16H2,1-2H3,(H,23,27)/b9-6-,15-14+/t17-,18+,19+,20-,21+/m0/s1. InChi Key: HLETUMXUCSCVPL-GWSKAPOCSA-N.