Prostaglandin E1-d4

Prostaglandin E1-d4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay313010-50 50 µg -

3 - 10 business days*

Cay313010-100 100 µg -

3 - 10 business days*

Cay313010-500 500 µg -

3 - 10 business days*

Prostaglandin E1-d4 (PGE1-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It... more
Product information "Prostaglandin E1-d4"
Prostaglandin E1-d4 (PGE1-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGE1 by GC- or LC-mass spectrometry. PGE1 is the theoretical cyclooxygenase metabolite of dihomo-gamma-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals. Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM. The vasorelaxant and anti-hypertensive effects of PGE1 are used to treat male erectile dysfunction and to provide emergency vasodilation of the patent ductus arteriosus in infants whose cardiac anomalies require pulmonary shunting for survival. In human males, the intracavernosal effective dose range for PGE1 is 2 to 80 µg, and the transurethral range is 125 to 1,000 µg. Formal Name: 9-oxo-11alpha,15S-dihydroxy-prost-13E-en-1-oic-3,3,4,4-d4 acid. CAS Number: 211105-33-8. Synonyms: Alprostadil-d4, PGE1-d4. Molecular Formula: C20H30D4O5. Formula Weight: 358.5. Purity: >99% deuterated forms (d1-d4). Formulation: A solution in methyl acetate. Solubility: DMF: >100 mg/ml (from PGE1), DMSO: >50 mg/ml (from PGE1), Ethanol: >50 mg/ml (from PGE1), PBS pH 7.2: >1.6 mg/ml (from PGE1). SMILES: CCCCC[C@@H](O)/C=C/[C@H]([C@H]1CCCC([2H])([2H])C([2H])([2H])CC(O)=O)[C@H](O)CC1=O. InChi Code: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1/i5D2,8D2. InChi Key: GMVPRGQOIOIIMI-HKEIXBCBSA-N.
Keywords: Alprostadil-d4, PGE1-d4, 9-oxo-11alpha,15S-dihydroxy-prost-13E-en-1-oic-3,3,4,4-d4 acid
Supplier: Cayman Chemical
Supplier-Nr: 313010


Application: Standard
MW: 358.5 D
Formula: C20H30D4O5
Purity: >99% deuterated forms (d1-d4)
Format: Solution

Database Information

CAS : 211105-33-8| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: EUH066, H225, H319, H336
P Phrases: , P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
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