Prostaglandin D2-d4

Prostaglandin D2-d4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay312010-25 25 µg -

5 - 10 business days*

94.00€
Cay312010-50 50 µg -

5 - 10 business days*

179.00€
Cay312010-100 100 µg -

5 - 10 business days*

338.00€
 
Prostaglandin D2-d4 (PGD2-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It... more
Product information "Prostaglandin D2-d4"
Prostaglandin D2-d4 (PGD2-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGD2 by GC- or LC-mass spectrometry. PGD2 is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD2 is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as beta-trace.2,3 In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 inhibits human ovarian tumor cell proliferation with an IC50 of 6.8 µM. Formal Name: 9alpha,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic-3,3,4,4-d4 acid. CAS Number: 211105-29-2. Synonyms: PGD2-d4. Molecular Formula: C20H28D4O5. Formula Weight: 356.5. Purity: >99% deuterated forms (d1-d4). Formulation: A solution in methyl acetate. Solubility: DMF: >100 mg/ml (from PGD2), DMSO: >50 mg/ml (from PGD2), Ethanol: >75 mg/ml (from PGD2), PBS pH 7.2: >5 mg/ml (from PGD2). SMILES: O[C@@H](C1)[C@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)C1=O. InChi Code: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1/i5D2,8D2. InChi Key: BHMBVRSPMRCCGG-DCNIGHKFSA-N.
Keywords: PGD2-d4, 9alpha,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic-3,3,4,4-d4 acid
Supplier: Cayman Chemical
Supplier-Nr: 312010

Properties

Application: Standard
MW: 356.5 D
Formula: C20H28D4O5
Purity: >99% deuterated forms (d1-d4)
Format: Solution

Database Information

CAS : 211105-29-2| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: EUH066, H225, H319, H336
P Phrases: , P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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