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Piriprost is a structural analog of prostaglandin I2 (PGI2) with low IP receptor-mediated activity. Piriprost inhibits 5-lipoxygenase with an IC50 around 100 µM, as measured by the release of 5-HETE from cultured myometrial cells. Piriprost inhibits the release of histamine and leukotrienes from isolated porcine lung cells with an IC50 of 0.11 µM, implicating its role in inflammation and allergic responses. Formal Name: 1,4(R),5(R),6-tetrahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-1-octenyl]-1-phenyl-cyclopenta[b]pyrrole-2-pentanoic acid, monopotassium salt. CAS Number: 88851-62-1. Synonyms: U-60257B. Molecular Formula: C26H34NO4 . K. Formula Weight: 463.7. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 8.6 mg/ml, DMSO: 30 mg/ml, Ethanol: 43 mg/ml, PBS (7.2): 0.5 mg/ml. lambdamax: 239 nm. SMILES: CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC2=C1C=C(CCCCC([O-])=O)N2C3=CC=CC=C3.[K+]. InChi Code: InChI=1S/C26H35NO4.K/c1-2-3-5-13-21(28)15-16-22-23-17-20(12-8-9-14-26(30)31)27(24(23)18-25(22)29)19-10-6-4-7-11-19,/h4,6-7,10-11,15-17,21-22,25,28-29H,2-3,5,8-9,12-14,18H2,1H3,(H,30,31),/q,+1/p-1/b16-15+,/t21-,22+,25+,/m0./s1. InChi Key: UFJDMFZMRXDIKI-FFGYHVHASA-M.
U-60257B, 1,4(R),5(R),6-tetrahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-1-octenyl]-1-phenyl-cyclopenta[b]pyrrole-2-pentanoic acid, monopotassium salt