Oleoyl Serinol

Oleoyl Serinol
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13637-5 5 mg -

6 - 10 business days*

56.00€
Cay13637-10 10 mg -

6 - 10 business days*

105.00€
Cay13637-50 50 mg -

6 - 10 business days*

431.00€
Cay13637-100 100 mg -

6 - 10 business days*

751.00€
 
Oleoyl serinol is an analog of ceramide and an agonist of the cannabinoid receptor GPR119 that... more
Product information "Oleoyl Serinol"
Oleoyl serinol is an analog of ceramide and an agonist of the cannabinoid receptor GPR119 that has an EC50 value of 12 µM for stimulating secretion of GLP-1 in mouse endocrine GLUTag cells. It has been found in E. coli that express human microbiota N-acyl synthase (hmNAS) genes. It induces cell death of F-11 murine neuroblastoma and apoptosis in U-87 human astrocytoma cells when used at a concentration of 100 µM. Oleoyl serinol (80 µM) induces formation of a complex including PAR-4 and PKCzeta in embryoid body-derived cells, decreases the levels of the pluripotency marker Oct-4 and prostate apoptosis response-4 (PAR-4), which mediates ceramide-induced apoptosis in embryonic stem cells. It induces apoptosis selectively in rapidly dividing cells over differentiated cells as well as prevents teratoma formation and promotes neural differentiation in a neonatal mouse engraftment model of teratoma formation.Formal Name: N-[2-hydroxy-1-(hydroxymethyl)ethyl]-9Z-octadecenamide. CAS Number: 72809-08-6. Synonyms: N-Oleoyl Serinol, S-18. Molecular Formula: C21H41NO3. Formula Weight: 355.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: >30 mg/ml, DMSO: >15 mg/ml, Ethanol: >30 mg/ml, PBS (pH 7.2): >290 µg/ml. SMILES: O=C(NC(CO)CO)CCCCCCC/C=C\CCCCCCCC. InChi Code: InChI=1S/C21H41NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(25)22-20(18-23)19-24/h9-10,20,23-24H,2-8,11-19H2,1H3,(H,22,25)/b10-9-. InChi Key: LGDVTFHRZXBSJM-KTKRTIGZSA-N.
Keywords: N-Oleoyl Serinol, S-18, N-[2-hydroxy-1-(hydroxymethyl)ethyl]-9Z-octadecenamide
Supplier: Cayman Chemical
Supplier-Nr: 13637

Properties

Application: GPR119 agonist
MW: 355.6 D
Formula: C21H41NO3
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 72809-08-6| Matching products
KEGG ID : K08424 | Matching products

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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