Loratadine-d4

Loratadine-d4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay26759-500 500 µg -

6 - 10 business days*

125.00€
Cay26759-1 1 mg -

6 - 10 business days*

236.00€
 
Loratadine-d4 is intended for use as an internal standard for the quantification of loratadine... more
Product information "Loratadine-d4"
Loratadine-d4 is intended for use as an internal standard for the quantification of loratadine (Cay-15625) by GC- or LC-MS. Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM). It has been shown to inhibit the release of leukotriene C4 (IC50 = 8 µM) and histamine (IC50 = 11 µM) from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs with an ED50 value of 0.40 mg/kg. Formulations containing loratadine have been used in the treatment of allergic rhinitis and chronic idiopathic urticaria.Formal Name: 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidine-3,3,5,5-d4-carboxylic acid, ethyl ester. CAS Number: 2748435-73-4. Molecular Formula: C22H19ClD4N2O2. Formula Weight: 386.9. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 30 mg/ml. SMILES: ClC(C=C1)=CC(CCC2=C/3N=CC=C2)=C1C3=C4C([2H])([2H])CN(C(OCC)=O)CC/4([2H])[2H]. InChi Code: InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3/i9D2,10D2. InChi Key: JCCNYMKQOSZNPW-YQUBHJMPSA-N.
Keywords: ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate-3,3,5,5-d4
Supplier: Cayman Chemical
Supplier-Nr: 26759

Properties

Application: GC-MS, LC-MS, quantification, internal standard, histamine H1 receptor antagonist
MW: 386.9 D
Formula: C22H19ClD4N2O2
Purity: >99% deuterated forms (d1-d4)
Format: Solid

Database Information

CAS : 2748435-73-4| Matching products
KEGG ID : K04149 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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