Leukotriene B4 Ethanolamide

Leukotriene B4 Ethanolamide
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay20112-25 25 µg -

6 - 10 business days*

140.00€
Cay20112-50 50 µg -

6 - 10 business days*

267.00€
Cay20112-100 100 µg -

6 - 10 business days*

504.00€
 
The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2. LTB4 is... more
Product information "Leukotriene B4 Ethanolamide"
The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2. LTB4 is a high affinity ligand for BLT1, and many of its pro-inflammatory effects are believed to be transduced through this receptor. The BLT2 is more enigmatic, in that LTB4 is not a high-affinity ligand, nor is it clear that BLT2 activation promotes inflammation. LTB4 ethanolamide (LTB4-EA) is a theoretical 5-LO metabolite of arachidonoyl ethanolamide (AEA). In CHO cells transfected with human BLTR1, LTB4-EA was a potent antagonist with about three times greater affinity for the receptor than LTB4 (Ki = 1.22 nM versus 3.88 nM). LTB4-EA antagonizes the LTB4-induced contractions of guinea pig lung parenchyma with an EC50 of 10 nM. LTB4-EA thus represents a potential endogenous anti-inflammatory compound functioning as a natural antagonist of BLTR1. Formal Name: N-(2-hydroxyethyl)-5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenamide. CAS Number: 877459-63-7. Synonyms: LTB4-EA. Molecular Formula: C22H37NO4. Formula Weight: 379.5. Purity: >97%. Formulation: A solution in ethanol. Solubility: DMF: 100 mg/ml, DMSO: 100 mg/ml, Ethanol: 100 mg/ml, PBS (pH 7.2): 12 mg/ml. lambdamax: 270 nm. SMILES: CCCCC/C=C\C[C@@H](O)/C=C/C=C\C=C\[C@@H](O)CCCC(=O)NCCO. InChi Code: InChI=1S/C22H37NO4/c1-2-3-4-5-6-9-13-20(25)14-10-7-8-11-15-21(26)16-12-17-22(27)23-18-19-24/h6-11,14-15,20-21,24-26H,2-5,12-13,16-19H2,1H3,(H,23,27)/b8-7+,9-6-,14-10+,15-11-/t20-,21-/m1/s1. InChi Key: DQLVVNIINUTUIU-XLFGVTECSA-N.
Keywords: LTB4-EA, N-(2-hydroxyethyl)-5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenamide
Supplier: Cayman Chemical
Supplier-Nr: 20112

Properties

Application: LTB4 receptor antagonist
MW: 379.5 D
Formula: C22H37NO4
Purity: >97%
Format: Solution

Database Information

CAS : 877459-63-7| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225
P Phrases: P210, P233, P240, P241, P242, P243, P280, P303+361+353, P370+378, P403+235, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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