Latanoprost ethyl amide

Latanoprost ethyl amide
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay16822-1 1 mg -

6 - 10 business days*

74.00€
Cay16822-5 5 mg -

6 - 10 business days*

333.00€
Cay16822-10 10 mg -

6 - 10 business days*

590.00€
 
Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has... more
Product information "Latanoprost ethyl amide"
Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity. Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 µg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides. Formal Name: N-ethyl-9alpha,11alpha,15R-trihydroxy-17-phenyl-18,19,20-trinor-prost-5Z-en-1-amide. CAS Number: 607351-44-0. Synonyms: Lat-NEt. Molecular Formula: C25H39NO4. Formula Weight: 417.6. Purity: >98%. Formulation: A solution in methyl acetate. Solubility: DMF: 30 mg/ml, DMSO: 50 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 200 µg/ml. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(N([H])CC)=O)[C@@H](CC[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1. InChi Code: InChI=1S/C25H39NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,20-24,27-29H,2,4,9,12-18H2,1H3,(H,26,30)/b8-3-/t20-,21+,22+,23-,24+/m0/s1. InChi Key: KNXVTDOCIZLXFW-SQACBOECSA-N.
Keywords: Lat-NEt, N-ethyl-9alpha,11alpha,15R-trihydroxy-17-phenyl-18,19,20-trinor-prost-5Z-en-1-amide
Supplier: Cayman Chemical
Supplier-Nr: 16822

Properties

Application: Bioactive lipid assays
MW: 417.6 D
Formula: C25H39NO4
Purity: >98%
Format: Solution

Database Information

CAS : 607351-44-0| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: EUH066, H225, H319, H336, H360
P Phrases: , P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P308+313, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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