L-161,982

L-161,982
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10011565-1 1 mg -

6 - 10 business days*

50.00€
Cay10011565-5 5 mg -

6 - 10 business days*

216.00€
Cay10011565-10 10 mg -

6 - 10 business days*

403.00€
Cay10011565-25 25 mg -

6 - 10 business days*

942.00€
 
Prostaglandin E2 (PGE2) exerts its effects through four separate G coupled-protein receptors... more
Product information "L-161,982"
Prostaglandin E2 (PGE2) exerts its effects through four separate G coupled-protein receptors (EP1-4). L-161,982 is a potent and selective EP4 receptor antagonist. It demonstrates selective binding to human EP4 receptors with a Ki value of 0.024 µM compared to other receptors of the prostanoid family, EP1, EP2, EP3, DP, FP, and IP, with Ki values of 17, 23, 1.9, 5.1, 5.6, and 6.7 µM, respectively. L-161,982 at 10 mg/kg/day suppresses PGE2-stimulated bone formation in young rats and at 100 nM reverses the anti-inflammatory action of PGE2 in LPS-activated human macrophages. At 10 µM L-161982 blocks PGE2-induced cell proliferation in HCA-7 colon cancer cells.Formal Name: N-[[4'-[[3-butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide. CAS Number: 147776-06-5. Molecular Formula: C32H29F3N4O4S2. Formula Weight: 654.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 10 mg/ml. lambdamax: 249 nm. SMILES: CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1sccc1C)c1ccccc1C(F)(F)F. InChi Code: InChI=1S/C32H29F3N4O4S2/c1-3-4-13-28-36-39(26-11-7-6-10-25(26)32(33,34)35)31(41)38(28)20-22-14-16-23(17-15-22)24-9-5-8-12-27(24)45(42,43)37-30(40)29-21(2)18-19-44-29/h5-12,14-19H,3-4,13,20H2,1-2H3,(H,37,40). InChi Key: MMDNKTXNUZFVKD-UHFFFAOYSA-N.
Keywords: N-[[4'-[[3-butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide
Supplier: Cayman Chemical
Supplier-Nr: 10011565

Properties

Application: EP4 receptor antagonist
MW: 654.7 D
Formula: C32H29F3N4O4S2
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 147776-06-5| Matching products
KEGG ID : K04261 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "L-161,982"
Write a review
or to review a product.
Viewed