Globotriaosylceramide (porcine RBC)

Globotriaosylceramide (porcine RBC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay24870-1 1 mg -

6 - 10 business days*

611.00€
Cay24870-10 10 mg -

6 - 10 business days*

4,624.00€
 
Globotriaosycleramides are glycosphingolipids found in mammalian cell membranes that are... more
Product information "Globotriaosylceramide (porcine RBC)"
Globotriaosycleramides are glycosphingolipids found in mammalian cell membranes that are synthesized from lactosylceramides (Cay-16983). They act as receptors for Shiga and Shiga-like toxins in vitro and in vivo. Globotriaosylceramides accumulate in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme alpha-galactosidase A. Globotriaosylceramides act as natural resistance factors to HIV infection, interacting with HIV gp120 to prevent its interaction with chemokine co-receptors and subsequent fusion of HIV to host cell membranes. This product contains globotriaosylceramides with primarily C24:0, 2-hydroxy C24:0, and C22:0 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1067]Formal Name: 1-O-(O-alpha-D-galactopyranosyl-(1->4)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl)-ceramide. CAS Number: 71965-57-6. Synonyms: Ceramide Trihexosides (porcine). Molecular Formula: C60H113NO18 (for tetracosanoyl). Formula Weight: 1136.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble (warmed). SMILES: O[C@H]1[C@H](O[C@]2([H])O[C@H](CO)[C@H](O[C@]3([H])[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)[C@H](O)[C@H]2O)[C@@H](CO)O[C@@H](OC[C@H](NC([R])=O)[C@H](O)/C=C/CCCCCCCCCCCCC)[C@@H]1O.
Keywords: Ceramide Trihexosides (porcine), 1-O-(O-alpha-D-galactopyranosyl-(1->4)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl)-ceramide
Supplier: Cayman Chemical
Supplier-Nr: 24870

Properties

Application: Mixture
MW: 1136.6 D
Formula: C60H113NO18 (tetracosanoyl)
Purity: >98%
Format: Solid

Database Information

CAS : 71965-57-6| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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