Fluprostenol isopropyl ester

Fluprostenol isopropyl ester
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay16769-1 1 mg -

6 - 10 business days*

70.00€
Cay16769-5 5 mg -

6 - 10 business days*

315.00€
Cay16769-10 10 mg -

6 - 10 business days*

560.00€
 
Fluprostenol isopropyl ester is an analog of prostaglandin F2alpha (PGF2alpha, Cay-16010,... more
Product information "Fluprostenol isopropyl ester"
Fluprostenol isopropyl ester is an analog of prostaglandin F2alpha (PGF2alpha, Cay-16010, Cay-16020) and an isopropyl ester prodrug form of (+)-fluprostenol (Cay-16768). Fluprostenol isopropyl ester is an FP receptor agonist, inducing phosphoinositide turnover in HEK293 cells expressing the human ocular FP receptor with an EC50 value of 40.2 nM. Topical application of fluprostenol isopropyl ester (0.01, 0.03, and 0.1 µg) induces miosis in conscious cats in a dose-dependent manner. It reduces intraocular pressure in a cynomolgus monkey model of ocular hypertension when administered topically at doses of 0.1 and 0.3 µg twice per day. Formulations containing fluprostenol isopropyl ester have been used in the treatment of open-angle glaucoma and ocular hypertension. Formal Name: 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5Z-heptenoic acid, 1-methylethyl ester. CAS Number: 157283-68-6. Synonyms: AL-6221, Flu-Ipr, 16-m-trifluoromethylphenoxy tetranor PGF2alpha isopropyl ester, Travoprost. Molecular Formula: C26H35F3O6. Formula Weight: 500.6. Purity: >98%. Formulation: A solution in ethanol. Solubility: DMF: 30 mg/ml, DMF:PBS (1:1): 500 µg/ml, DMSO: 20 mg/ml, Ethanol: 25 mg/ml. lambdamax: 222, 280 nm. SMILES: O[C@@H](C[C@H]([C@@H]1/C=C/[C@@H](O)COC2=CC=CC(C(F)(F)F)=C2)O)[C@@H]1C/C=C\CCCC(OC(C)C)=O. InChi Code: InChI=1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1. InChi Key: MKPLKVHSHYCHOC-AHTXBMBWSA-N.
Keywords: 16-m-trifluoromethylphenoxy tetranor PGF2alpha isopropyl ester, AL-6221, Flu-Ipr, Travoprost, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5Z-heptenoic acid, 1-methylethyl ester
Supplier: Cayman Chemical
Supplier-Nr: 16769

Properties

Application: Bioactive lipid assays
MW: 500.6 D
Formula: C26H35F3O6
Purity: >98%
Format: Solution

Database Information

CAS : 157283-68-6| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H360
P Phrases: P201, P202, P210, P233, P240, P241, P242, P243, P280, P303+361+353, P308+313, P370+378, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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