DC-Chol (hydrochloride)

DC-Chol is a cationic cholesterol derivative. DC-Chol, as a component of lipoplexes with 1,2-Dioleoyl-sn-glycero-3-PE (1,2-DOPE, Cay-15091), has been used for transfection of mRNA into A549 cells without affecting cell viability. Incubation of DC-chol/1,2-DOPE liposomes or lipoplexes with human whole blood has no effect on neutrophil elastase or beta-thromboglobulin levels or the number of platelets and red and white blood cells, indicating hemocompatibility. DC-Chol has also been widely used in the synthesis of liposomes for the delivery of siRNA, DNA, and chemotherapeutic agents into cells and mice.Formal Name: (3beta)-cholest-5-en-3-ol 3-[N-[2-(dimethylamino)ethyl]carbamate], monohydrochloride. CAS Number: 166023-21-8. Synonyms: Cholesteryl 3beta-N-(dimethylaminoethyl)carbamate. Molecular Formula: C32H56N2O2 . HCl. Formula Weight: 537.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: >5 mg/ml, Methanol: >10 mg/ml. SMILES: CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(NCCN(C)C)=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.Cl. InChi Code: InChI=1S/C32H56N2O2.ClH/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-24-21-25(36-30(35)33-19-20-34(6)7)15-17-31(24,4)29(26)16-18-32(27,28)5,/h11,22-23,25-29H,8-10,12-21H2,1-7H3,(H,33,35),1H/t23-,25+,26+,27-,28+,29+,31+,32-,/m1./s1. InChi Key: ISXSJGHXHUZXNF-LXZPIJOJSA-N.