Cyclopentenone Prostaglandin HPLC Mixture

This mixture contains all of the major UV-absorbing cyclopentenone prostaglandins and their precursors. Contents: 100 µg of each compound Prostaglandin A2 (Cay-10210) Prostaglandin B2 (Cay-11210) Prostaglandin D2 (Cay-12010) Prostaglandin E2 (Cay-14010) Prostaglandin J2 (Cay-18500) 15-deoxy-Delta12,14-Prostaglandin J2 (Cay-18570) PGE2 and PGD2 are both chemically unstable. In the absence of any enzymatic influence, both are undergo dehydration to form the highly UV active cyclopentenone compounds PGA2 and PGJ2, respectively. These compounds absorb in the ultraviolet with maxima at 216 - 220 lambda. The cyclopentenone prostaglandins have been noted to have antimitotic, antiviral and antitumor activity in a number of systems. PGA2 and PGJ2, can also undergo further elimination and double bond rearrangements to give PGB2 and 15-deoxy-Delta12,14 PGJ2, respectively. 15-deoxy-Delta12,14 PGJ2 is a relatively potent ligand for the PPARgamma nuclear receptor. PGB2 does not appear to have significant intrinsic biological activity, however, it is frequently used as a reliable internal standard for analysis of eicosanoids by HPLC.