(+)-Cloprostenol

(+)-Cloprostenol is a synthetic analog of prostaglandin F2alpha (PGF2alpha). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. (+)-Cloprostenol is the optically active, 15(R) enantiomer of cloprostenol responsible for the majority of its biological activity. It is 200 times more potent than PGF2alpha in terminating pregnancy when given subcutaneously at a daily dose of 0.125 µg/kg in rats and hamsters, without the side effects associated with PGF2alpha. (+)-Cloprostenol was also shown to be a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 value of 3 pM.Formal Name: (+)-9alpha,11alpha,15R-trihydroxy-16-(3-chlorophenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid. CAS Number: 54276-21-0. Synonyms: D-Cloprostenol, (+)-16-m-chlorophenoxy tetranor PGF2alpha, (+)-16-m-chlorophenoxy tetranor Prostaglandin F2alpha. Molecular Formula: C22H29ClO6. Formula Weight: 424.9. Purity: >97%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: >100 mg/ml, DMSO: >100 mg/ml, Ethanol: >100 mg/ml, PBS pH 7.2: >16 mg/ml. lambdamax: 220, 275, 282 nm. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)COC2=CC=CC(Cl)=C2)[C@H](O)C1. InChi Code: InChI=1S/C22H29ClO6/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1. InChi Key: VJGGHXVGBSZVMZ-QIZQQNKQSA-N.