C-12 NBD Ceramide

C-12 NBD Ceramide
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10007958-1 1 mg -

6 - 10 business days*

Cay10007958-5 5 mg -

6 - 10 business days*

Cay10007958-10 10 mg -

6 - 10 business days*

Ceramidase catalyzes the hydrolysis of the N-acyl linkage between the fatty acid and sphingosine... more
Product information "C-12 NBD Ceramide"
Ceramidase catalyzes the hydrolysis of the N-acyl linkage between the fatty acid and sphingosine base in ceramide to produce sphingosine and a free fatty acid. Three isoforms of ceramidases (acid, neutral, and alkaline) have been characterized based on differences in their catalytic pH optimum. C12 NBD ceramide (d18:1/12:0) is a long-chain fluorescent ceramide analog that can be used for the measurement of alkaline and neutral ceramidase activity. It is hydrolyzed efficiently by alkaline ceramidase from P. aeruginosa and by neutral ceramidase from mouse liver. In addition, alkaline and neutral ceramidases from a variety of mammalian cell lines also hydrolyze C12 NBD ceramide (d18:1/12:0). Acid ceramidase does not appear to utilize C-12 NBD ceramide as a substrate. The possibility exists for C12 NBD ceramide (d18:1/12:0) to also be applied to the measurement of ceramide kinase and/or sphingomyelin synthase activity. Formal Name: N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-dodecanamide. CAS Number: 202850-01-9. Synonyms: NBD Cer(d18:1/12:0), NBD Ceramide (d18:1/12:0), N-C12-NBD-D-erythro-Sphingosine. Molecular Formula: C36H61N5O6. Formula Weight: 659.9. Purity: >98%. Formulation: A solution in chloroform. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. lambdamax: 242, 337, 477 nm. SMILES: OC[C@H](NC(CCCCCCCCCCCNC1=CC=C([N+]([O-])=O)C2=NON=C12)=O)[C@H](O)/C=C/CCCCCCCCCCCCC. InChi Code: InChI=1S/C36H61N5O6/c1-2-3-4-5-6-7-8-9-10-12-15-18-21-24-33(43)31(29-42)38-34(44)25-22-19-16-13-11-14-17-20-23-28-37-30-26-27-32(41(45)46)36-35(30)39-47-40-36/h21,24,26-27,31,33,37,42-43H,2-20,22-23,25,28-29H2,1H3,(H,38,44)/b24-21+/t31-,33+/m0/s1. InChi Key: SNOJCYCOPNIGIK-ULETYAGTSA-N.
Keywords: N-C12-NBD-D-erythro-Sphingosine, NBD Cer(d18:1/12:0), NBD Ceramide (d18:1/12:0), N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-dodecanamide
Supplier: Cayman Chemical
Supplier-Nr: 10007958


Application: Bioactive lipid assays
MW: 659.9 D
Formula: C36H61N5O6
Purity: >98%
Format: Solution

Database Information

CAS : 202850-01-9| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H331, H351, H361, H372
P Phrases: P201, P202, P260, P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P308+313, P311, P314, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501
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