BW A868C

BW A868C is a hydantoin compound that is structurally related to the DP receptor agonist BW 245C. BW A868C antagonizes the prostaglandin D2 and BW 245C-induced activation of human platelet adenylate cyclase. It reverses the anti-aggregatory effects of DP receptor agonists in a dose-dependent manner. Likewise, BW A868C antagonizes the accumulation of cAMP in rabbit non-pigmented ciliary epithelial cells. It has virtually no effect on human TP, IP, EP1, EP2, and FP receptors. The Ki for BW A868C is approximately 1.7 nM.Formal Name: 3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-4-imidazolidineheptanoic acid. CAS Number: 118675-50-6. Molecular Formula: C25H37N3O5. Formula Weight: 459.6. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 250 µg/ml. SMILES: O=C1C(CCCCCCC(O)=O)N(NCC(O)C2CCCCC2)C(N1CC3=CC=CC=C3)=O. InChi Code: InChI=1S/C25H37N3O5/c29-22(20-13-7-4-8-14-20)17-26-28-21(15-9-1-2-10-16-23(30)31)24(32)27(25(28)33)18-19-11-5-3-6-12-19/h3,5-6,11-12,20-22,26,29H,1-2,4,7-10,13-18H2,(H,30,31). InChi Key: YZJVWSKJHGEIBL-UHFFFAOYSA-N.