Lipids

Lipids are organic small molecules, that are usually hydrophobic or amphiphillic. This group includes fat, fatty acids, waxes, triglycerides, sterols and phospholipids for example. Lipids are the main structural component of biological membranes of all cells. As such bacterial lipid structures and glycolipids can serve as pathogen-associated-molecular-patterns (PAMPs) and are recognized by our immune system. Various lipids of bacterial origin are therefore used as immunostimulants.

Lipids are organic small molecules, that are usually hydrophobic or amphiphillic. This group includes fat, fatty acids, waxes, triglycerides, sterols and phospholipids for example. Lipids are the... read more »
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Lipids

Lipids are organic small molecules, that are usually hydrophobic or amphiphillic. This group includes fat, fatty acids, waxes, triglycerides, sterols and phospholipids for example. Lipids are the main structural component of biological membranes of all cells. As such bacterial lipid structures and glycolipids can serve as pathogen-associated-molecular-patterns (PAMPs) and are recognized by our immune system. Various lipids of bacterial origin are therefore used as immunostimulants.

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Arachidonic Acid
Arachidonic Acid

Item number: Cay90010-100

Arachidonic acid is an essential fatty acid and a precursor for all prostaglandins, thromboxanes, and leukotrienes. Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free arachidonic acid is a transient,...
Keywords: AA, 5Z,8Z,11Z,14Z-eicosatetraenoic acid
Application: Bioactive lipid assays
CAS 506-32-1
MW: 304.5 D
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(±)9-HODE
(±)9-HODE

Item number: Cay38400-100

(±)9-HODE is one of the two racemic monohydroxy fatty acids resulting from the non-enzymatic oxidation of linoleic acid. Approximately equal proportions of both isomers are found in mitochondrial and plasma membranes of rabbit reticulocytes. Oxidized LDL contains significant amounts of esterified 9- and 13-HpODEs...
Keywords: (±)-9-hydroxy-10E,12Z-octadecadienoic acid
Application: Bioactive lipid studies
CAS 98524-19-7
MW: 296.5 D
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15-keto Prostaglandin E1
15-keto Prostaglandin E1

Item number: Cay13680-1

15-keto PGE1 is the inactive metabolite of PGE1 produced by 15-hydroxy PGDH. It has greatly diminished biological activity compared to PGE1. Formal Name: 9,15-dioxo-11alpha-hydroxy-prost-13E-en-1-oic acid. CAS Number: 22973-19-9. Synonyms: 15-keto PGE1. Molecular Formula: C20H32O5. Formula Weight: 352.5. Purity:...
Keywords: 15-keto PGE1, 9,15-dioxo-11alpha-hydroxy-prost-13E-en-1-oic acid
Application: Bioactive lipid assays
CAS 22973-19-9
MW: 352.5 D
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15-deoxy-Delta12,14-Prostaglandin J2
15-deoxy-Delta12,14-Prostaglandin J2

Item number: Cay18570-1

15-deoxy-Delta12,14-Prostaglandin J2 (15-deoxy-Delta12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARgamma with an EC50 value of 2 µM in a murine chimera system. 15-deoxy-Delta12,14-PGJ2 is more potent than PGD2, Delta12-PGJ2, and PGJ2 in stimulating...
Keywords: 15-deoxy-Delta12,14-PGJ2, 11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oic acid
Application: Bioactive lipid assays
CAS 87893-55-8
MW: 316.4 D
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Resolvin D1
Resolvin D1

Item number: Cay10012554-10

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA, Cay-90110) and docosahexaenoic acid (DHA, Cay-90310). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D1 (RvD1) is produced...
Keywords: 17(S)-Resolvin D1, RvD1, 7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-docosahexaenoic acid
Application: Bioactive lipid assays
CAS 872993-05-0
MW: 376.5 D
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8-iso Prostaglandin F2alpha
8-iso Prostaglandin F2alpha

Item number: Cay16350-1

8-iso PGF2alpha is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2alpha...
Keywords: 15-F2t-Isoprostane, 8-epi PGF2alpha, 8-iso-15(S)-Prostaglandin F2alpha, 8-Isoprostane, iPF2alpha-III,...
Application: TP receptor agonist
CAS 27415-26-5
MW: 354.5 D
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Prostaglandin I2 (sodium salt)
Prostaglandin I2 (sodium salt)

Item number: Cay18220-1

Prostaglandin I2 (PGI2) is an unstable cyclooxygenase metabolite detected first in vascular endothelial cells. It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC50 of 5 nM. PGI2 is stable in basic buffers (pH=8), but it is rapidly hydrolyzed to 6-keto...
Keywords: Epoprostenol, PGI2, Prostacyclin, 6,9alpha-epoxy-11alpha,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid, monosodium salt
Application: Bioactive lipid assays
CAS 61849-14-7
MW: 374.5 D
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N-3-oxo-dodecanoyl-L-Homoserine lactone
N-3-oxo-dodecanoyl-L-Homoserine lactone

Item number: Cay10007895-1

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. A promising field of study involves controlling bacterial infections by quenching their quorum sensing systems. The expression of specific target genes, such as transcriptional regulators...
Keywords: 3-oxo-C12-HSL, 3-oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-dodecanamide
Application: Bioactive lipid assays
CAS 168982-69-2
MW: 297.4 D
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Eicosapentaenoic Acid
Eicosapentaenoic Acid

Item number: Cay90110-50

EPA is an omega-3 fatty acid abundantly available in marine organisms. It is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid. EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some...
Keywords: EPA, Timnodonic Acid, 5Z,8Z,11Z,14Z,17Z-eicosapentaenoic acid
Application: Bioactive lipid assays
CAS 10417-94-4
MW: 302.5 D
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Lipoxin A4
Lipoxin A4

Item number: Cay90410-25

Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE (Cay-34700) or 15-HpETE with human leukocytes. LXA4 is equipotent to leukotriene B4 (Cay-20110) in inducing superoxide generation in human neutrophils at 0.1 µM. LXA4 is associated with several...
Keywords: 5(S),6(R),15(S)-TriHETE, LXA4, 5S,6R,15S-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid
Application: Bioactive lipid assays
CAS 89663-86-5
MW: 352.5 D
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Indomethacin
Indomethacin

Item number: Cay70270-1000

Indomethacin is a non-selective COX inhibitor (IC50s = 1.67 and 24.6 µM for human COX-1 and COX-2, respectively). It reduces filter paper-disc induced growth of granulation tissue, a marker of inflammation, in chick chorioallantoic membranes. Indomethacin reduces ocular inflammation induced by bovine serum in...
Keywords: 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
Application: COX inhibitor
CAS 53-86-1
MW: 357.8 D
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Resolvin D2
Resolvin D2

Item number: Cay10007279-10

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA, Cay-90110) and docosahexaenoic acid (DHA, Cay-90310). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D2 (RvD2) is produced...
Keywords: 7(S),16(R),17(S)-Resolvin D2, RvD2, 7S,16R,17S-trihydroxy-4Z,8E,10Z,12E,14E,19Z-docosahexaenoic acid
Application: Lipid mediator
CAS 810668-37-2
MW: 376.5 D
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