9-keto Fluprostenol isopropyl ester

9-keto Fluprostenol isopropyl ester is an ester derivative of the FP receptor agonist fluprostenol (Cay-16768) that is oxidized at carbon 9. It is a potential prodrug to 9-keto fluprostenol (Cay-16781), which could act as an agonist at EP receptors. It is also a potential metabolite of fluprostenol isopropyl ester (travoprost, Cay-16769) based on the published metabolism of latanoprost (Cay-16812) by 15-hydroxyprostaglandin dehydrogenase in the monkey cornea. Certain F-series prostaglandins, such as 6-keto prostaglandin F1alpha (PGF1alpha, Cay-15210), are converted to the corresponding E-series compounds in isolated human platelets.Formal Name: (5Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-5-oxocyclopentyl]-5-heptenoic acid, 1-methylethyl ester. CAS Number: 1219032-18-4. Synonyms: Fluprostenol Prostaglandin E2. Molecular Formula: C26H33F3O6. Formula Weight: 498.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 30 mg/ml, DMF:PBS (1:1): 500 µg/ml, DMSO: 20 mg/ml, Ethanol: 25 mg/ml. lambdamax: 222, 277 nm. SMILES: O[C@H]1[C@H](/C=C/[C@@H](O)COC2=CC(C(F)(F)F)=CC=C2)[C@@H](C/C=C\CCCC(OC(C)C)=O)C(C1)=O. InChi Code: InChI=1S/C26H33F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-22,24,30,32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,24-/m1/s1. InChi Key: OKXNVRDMSRTJEN-FFKVAXMCSA-N.