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Product information "8-iso-17-phenyl trinor Prostaglandin F2alpha"
8-iso-17-phenyl trinor Prostaglandin F2alpha (8-iso-17-phenyl trinor PGF2alpha) is the C-8 epimer of bimatoprost (free acid), a metabolically stable analog of PGF2alpha. Bimatoprost (free acid) binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2alpha. At the rat recombinant FP receptor expressed in CHO cells bimatoprost inhibits PGF2alpha binding with a Ki of 1.1 nM. There are no published studies of the pharmacological properties of 8-iso-17-phenyl trinor PGF2alpha.Formal Name: 9alpha,11alpha,15S-trihydroxy-17-phenyl-18,19,20-trinor-(8beta)-prosta-5Z,13E-dien-1-oic acid. Molecular Formula: C23H32O5. Formula Weight: 388.5. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O[C@@H]1[C@@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1. InChi Code: InChI=1S/C23H32O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,14-15,18-22,24-26H,2,7,10-13,16H2,(H,27,28)/b6-1-,15-14+/t18-,19-,20+,21-,22+/m0/s1. InChi Key: YFHHIZGZVLHBQZ-ASXHZHNKSA-N.
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