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Product information "8-iso-13,14-dihydro-15-keto Prostaglandin F2alpha"
8-iso-13,14-dihydro-15-keto Prostaglandin F2alpha (8-iso-13,14-dihydro-15-keto PGF2alpha) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF2alpha), in rabbits, monkeys and humans. 8-iso PGF2alpha is a PG-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by beta-oxidation. A similar pattern is observed when tritiated 8-isoprostane is infused into rabbits. Early in the infusion (within 10 minutes) 8-iso-13,14-dihydro-15-keto PGF2alpha was a significant component of the metabolite profile, which was comprised mostly of dinor 8-isoprostane metabolites. 8-iso-13,14-dihydro-15-keto PGF2alpha weakly inhibits the U-46619 or collagen-induced aggregation of human platelets, although a number of the E-series isoprostanes are much more potent in this assay.Formal Name: (8beta)-9alpha,11alpha-dihydroxy-15-oxo-prost-5Z-en-1-oic acid. CAS Number: 191919-02-5. Synonyms: 8-iso-13,14-dihydro-15-keto PGF2alpha. Molecular Formula: C20H34O5. Formula Weight: 354.5. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: 10 mM Na2CO3: >6.5 mg/ml, DMF: >100 mg/ml, DMSO: >100 mg/ml, Ethanol: >100 mg/ml, PBS (pH 7.2): >10 mg/ml. SMILES: O[C@@H]1[C@@H](C/C=C\CCCC(O)=O)[C@@H](CCC(CCCCC)=O)[C@H](O)C1. InChi Code: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,16-19,22-23H,2-3,5-6,8-14H2,1H3,(H,24,25)/b7-4-/t16-,17+,18-,19+/m0/s1. InChi Key: VKTIONYPMSCHQI-JPRPWBOBSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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