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6beta-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6beta-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6beta-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 µM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.Formal Name: 6S,9alpha-epoxy-11alpha,15S-dihydroxy-prost-13E-en-1-oic acid. CAS Number: 62770-50-7. Synonyms: 6beta-PGI1, 5,6beta-dihydro PGI2. Molecular Formula: C20H34O5. Formula Weight: 354.5. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: >10 mg/ml, DMSO: >5 mg/ml, Ethanol: >20 mg/ml, PBS pH 7.2: >80 µg/ml. SMILES: CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C[C@@](CCCCC(O)=O)([H])O2. InChi Code: InChI=1S/C20H34O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h10-11,14-19,21-22H,2-9,12-13H2,1H3,(H,23,24)/b11-10+/t14-,15-,16+,17+,18+,19-/m0/s1. InChi Key: RJADQDXZYFCVHV-CBIPHORWSA-N.
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