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Product information "3-PT-PtdIns-(3,4,5)-P3 (1,2-dioctanoyl) (sodium salt)"
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns(4,5)-P2 can be phosphorylated by phosphoinositide (PI)-3-kinase to make PtdIns(3,4,5)-P3 which initiates an intricate signaling cascade that has been implicated in cancer. 3-PT-PtdIns(3,4,5)-P3 is an analog of PtdIns-(3,4,5)-P3 that is resistant to hydrolysis by PTEN. It has a 5-fold reduced affinity for the specific PtdIns(3,4,5)-P3-binding protein GRP1 and increases sodium transport in A6 cell monolayers. Formal Name: 1-(1,2-dioctanoylphosphatidyl)inositol-3-phosphorothioate-4,5-diphosphate, tetrasodium salt. Synonyms: 3-Phosphorothioate-Phosphatidylinositol-4,5-diphosphate C-8. Molecular Formula: C25H46O21P4S . 4Na. Formula Weight: 930.5. Purity: >98%. Formulation: A lyophilized powder. Solubility: Water: 10 mg/ml. SMILES: O=C(OC[C@H](COP(O[C@@H]1[C@H](O)[C@H](OP(O)([O-])=S)[C@@H](OP([O])(O)=O)[C@H](OP([O-])(O)=O)[C@H]1O)([O-])=O)OC(CCCCCCC)=O)CCCCCCC.[Na+].[Na].[Na+].[Na+]. InChi Code: InChI=1S/C25H50O21P4S.4Na/c1-3-5-7-9-11-13-18(26)40-15-17(42-19(27)14-12-10-8-6-4-2)16-41-49(36,37)45-22-20(28)23(43-47(30,31)32)25(44-48(33,34)35)24(21(22)29)46-50(38,39)51,,,,/h17,20-25,28-29H,3-16H2,1-2H3,(H,36,37)(H2,30,31,32)(H2,33,34,35)(H2,38,. InChi Key: VVBWSBAPPMPDDE-OHYVEFHDSA-J. Side Chain Carbon Sum: 16:0.
3-Phosphorothioate-Phosphatidylinositol-4,5-diphosphate C-8, 1-(1,2-dioctanoylphosphatidyl)inositol-3-phosphorothioate-4,5-diphosphate, tetrasodium salt