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During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer... more
Product information "(25S)-Delta7-Dafachronic Acid"
During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans. DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. (25S)-Delta7-Dafachronic acid is a sterol-derived hormone that acts as a ligand of DAF-12 with an EC50 value of 23 nM. At 50 nM, (25S)-Delta7-Dafachronic acid inhibits the dauer-promoting activity of DAF-12, blocking the formation of infective larvae in several parasitic nematodes in favor of reproductive maturation to adults. Thus, selective ligand modulators of DAF-12 are a potential therapeutic approach to stop larvae progression during parasitic infection.Formal Name: (5alpha,25S)-3-oxo-cholest-7-en-26-oic acid. CAS Number: 949004-12-0. Synonyms: (25S)-Delta7-DA, UPF-1404. Molecular Formula: C27H42O3. Formula Weight: 414.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 2.5 mg/ml, Ethanol: 12.5 mg/ml, Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml. SMILES: O=C1CC[C@@]2(C)[C@](CC=C3[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4[C@@H](CCC[C@H](C)C(O)=O)C)([H])C1. InChi Code: InChI=1S/C27H42O3/c1-17(6-5-7-18(2)25(29)30)22-10-11-23-21-9-8-19-16-20(28)12-14-26(19,3)24(21)13-15-27(22,23)4/h9,17-19,22-24H,5-8,10-16H2,1-4H3,(H,29,30)/t17-,18+,19+,22-,23+,24+,26+,27-/m1/s1. InChi Key: SQTAVUCHOVVOFD-OBRBSRNPSA-N.
Keywords: | UPF-1404, (5alpha,25S)-3-oxo-cholest-7-en-26-oic acid |
Supplier: | Cayman Chemical |
Supplier-Nr: | 14101 |
Properties
Application: | DAF-12 inhibitor |
MW: | 414.6 D |
Formula: | C27H42O3 |
Purity: | >95% |
Format: | Crystalline Solid |
Database Information
CAS : | 949004-12-0| Matching products |
KEGG ID : | K08701 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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