(25S)-Delta7-Dafachronic Acid

(25S)-Delta7-Dafachronic Acid
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14101-100 100 µg -

6 - 10 business days*

387.00€
Cay14101-500 500 µg -

6 - 10 business days*

1,547.00€
Cay14101-1 1 mg -

6 - 10 business days*

2,902.00€
 
During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer... more
Product information "(25S)-Delta7-Dafachronic Acid"
During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans. DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. (25S)-Delta7-Dafachronic acid is a sterol-derived hormone that acts as a ligand of DAF-12 with an EC50 value of 23 nM. At 50 nM, (25S)-Delta7-Dafachronic acid inhibits the dauer-promoting activity of DAF-12, blocking the formation of infective larvae in several parasitic nematodes in favor of reproductive maturation to adults. Thus, selective ligand modulators of DAF-12 are a potential therapeutic approach to stop larvae progression during parasitic infection.Formal Name: (5alpha,25S)-3-oxo-cholest-7-en-26-oic acid. CAS Number: 949004-12-0. Synonyms: (25S)-Delta7-DA, UPF-1404. Molecular Formula: C27H42O3. Formula Weight: 414.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 2.5 mg/ml, Ethanol: 12.5 mg/ml, Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml. SMILES: O=C1CC[C@@]2(C)[C@](CC=C3[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4[C@@H](CCC[C@H](C)C(O)=O)C)([H])C1. InChi Code: InChI=1S/C27H42O3/c1-17(6-5-7-18(2)25(29)30)22-10-11-23-21-9-8-19-16-20(28)12-14-26(19,3)24(21)13-15-27(22,23)4/h9,17-19,22-24H,5-8,10-16H2,1-4H3,(H,29,30)/t17-,18+,19+,22-,23+,24+,26+,27-/m1/s1. InChi Key: SQTAVUCHOVVOFD-OBRBSRNPSA-N.
Keywords: UPF-1404, (5alpha,25S)-3-oxo-cholest-7-en-26-oic acid
Supplier: Cayman Chemical
Supplier-Nr: 14101

Properties

Application: DAF-12 inhibitor
MW: 414.6 D
Formula: C27H42O3
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 949004-12-0| Matching products
KEGG ID : K08701 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "(25S)-Delta7-Dafachronic Acid"
Write a review
or to review a product.
Viewed