(25S)-Delta7-Dafachronic Acid

(25S)-Delta7-Dafachronic Acid
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14101-100 100 µg -

1 - 10 business days

Cay14101-500 500 µg -

1 - 10 business days

Cay14101-1 1 mg -

1 - 10 business days

During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer... more
Product information "(25S)-Delta7-Dafachronic Acid"
During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans. DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. (25S)-Delta7-Dafachronic acid is a sterol-derived hormone that acts as a ligand of DAF-12 with an EC50 value of 23 nM. At 50 nM, (25S)-Delta7-Dafachronic acid inhibits the dauer-promoting activity of DAF-12, blocking the formation of infective larvae in several parasitic nematodes in favor of reproductive maturation to adults. Thus, selective ligand modulators of DAF-12 are a potential therapeutic approach to stop larvae progression during parasitic infection.
Keywords: UPF-1404, (5alpha,25S)-3-oxo-cholest-7-en-26-oic acid
Supplier: Cayman Chemical
Supplier-Nr: 14101-1


Application: DAF-12 inhibitor
MW: 414.6 D
Formula: C27H42O3
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 949004-12-0| Find alternatives
KEGG ID : K08701 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Our products are for laboratory research use only: Not for administration to humans!
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