2-hydroxy Atorvastatin (calcium salt)

2-hydroxy Atorvastatin (calcium salt)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay30974-1 1 mg -

6 - 10 business days*

324.00€
 
2-hydroxy Atorvastatin is an active metabolite of the HMG-CoA reductase inhibitor atorvastatin... more
Product information "2-hydroxy Atorvastatin (calcium salt)"
2-hydroxy Atorvastatin is an active metabolite of the HMG-CoA reductase inhibitor atorvastatin (Cay-10493). 2-hydroxy Atorvastatin is formed from atorvastatin by the cytochrome P450 (CYP) isoform CYP3A4. It inhibits lipid hydroperoxide formation and copper sulfate-induced thiobarbituric acid reactive substances (TBARS) formation in 1,2-dilinoleoyl-sn-glycero-3-PC (DLPC, Cay-20954) vesicles and human LDL, respectively, in a concentration-dependent manner. 2-hydroxy Atorvastatin reduces cell death induced by oxygen-glucose deprivation (OGD) in primary rat cortical neurons and increases phosphorylation of cAMP-response-element-binding protein (CREB) in GABAergic neurons when used at a concentration of 600 nM following OGD.Formal Name: (betaR,deltaR)-2-(4-fluorophenyl)-beta,delta-dihydroxy-4-[[(2-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-phenyl-1H-pyrrole-1-heptanoic acid, calcium salt (2:1). CAS Number: 265989-46-6. Synonyms: o-hydroxy Atorvastatin, ortho-hydroxy Atorvastatin, BMS 243887-01, PD 152873. Molecular Formula: C33H34FN2O6 . 1/2Ca. Formula Weight: 593.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: O=C(C1=C(C(C)C)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C2=CC=C(F)C=C2)=C1C3=CC=CC=C3)NC4=CC=CC=C4O.O=C(C5=C(C(C)C)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C6=CC=C(F)C=C6)=C5C7=CC=CC=C7)NC8=CC=CC=C8O.[Ca+2]. InChi Code: InChI=1S/2C33H35FN2O6.Ca/c2*1-20(2)31-30(33(42)35-26-10-6-7-11-27(26)39)29(21-8-4-3-5-9-21)32(22-12-14-23(34)15-13-22)36(31)17-16-24(37)18-25(38)19-28(40)41,/h2*3-15,20,24-25,37-39H,16-19H2,1-2H3,(H,35,42)(H,40,41),/q,,+2/p-2/t2*24-,25-,/m11./s1. InChi Key: NOCWNJZXNVSDOU-LBSXWHBJSA-L.
Keywords: o-hydroxy Atorvastatin, ortho-hydroxy Atorvastatin, BMS 243887-01, PD 152873, (betaR,deltaR)-2-(4-fluorophenyl)-beta,delta-dihydroxy-4-[[(2-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-phenyl-1H-pyrrole-1-heptanoic acid, calcium salt (2:1)
Supplier: Cayman Chemical
Supplier-Nr: 30974

Properties

Application: Active metabolite (HMG-CoA reductase inhibitor)
MW: 593.7 D
Formula: C33H34FN2O6 . 1/2Ca
Purity: >95%
Format: Solid

Database Information

CAS : 265989-46-6| Matching products
KEGG ID : K00021 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H319
P Phrases: P264, P280, P305+351+338, P337+313
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "2-hydroxy Atorvastatin (calcium salt)"
Write a review
or to review a product.
Viewed