2-Arachidonoyl Glycerol

2-Arachidonoyl Glycerol
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay62160-1 1 mg -

3 - 10 business days*

Cay62160-5 5 mg -

3 - 10 business days*

Cay62160-10 10 mg -

3 - 10 business days*

Cay62160-25 25 mg -

approx. 1-3 business days

2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the cannabinoid (CB) receptors CB1 and... more
Product information "2-Arachidonoyl Glycerol"
2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the cannabinoid (CB) receptors CB1 and CB2 (Kis = 25.3-472 and 145-1,400 nM, respectively). Unlike arachidonoyl ethanolamide (AEA, Cay-90050), 2-AG is present at relatively high levels in the central nervous system and is the most abundant molecular species of monoacylglycerol (MAG) found in rat brain. Formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C (PLC) and diacylglycerol (DAG) lipase. 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3 nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism. 2-AG is metabolized in vitro by MAG lipase and fatty acid amide hydrolase (FAAH), with MAG lipase likely being the principle metabolizing enzyme in vivo. Formal Name: 5Z,8Z,11Z,14Z-eicosatetraenoic acid, 2-glyceryl ester. CAS Number: 53847-30-6. Synonyms: 2-AG. Molecular Formula: C23H38O4. Formula Weight: 378.6. Purity: >95% (as a 9:1 mixture of the 2-AG and 1-AG). Formulation: A solution in acetonitrile. Solubility: DMSO: 10 mg/ml, Ethanol: Miscible, PBS (pH 7.2): ~150 µg/ml. SMILES: CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)OC(CO)CO. InChi Code: InChI=1S/C23H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)27-22(20-24)21-25/h6-7,9-10,12-13,15-16,22,24-25H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-. InChi Key: RCRCTBLIHCHWDZ-DOFZRALJSA-N. Side Chain Carbon Sum: 20:4.
Keywords: 2-AG, 5Z,8Z,11Z,14Z-eicosatetraenoic acid, 2-glyceryl ester
Supplier: Cayman Chemical
Supplier-Nr: 62160


Application: CB1 receptor agonist
MW: 378.6 D
Formula: C23H38O4
Purity: >95% (as a 9:1 mixture of the 2-AG and 1-AG)
Format: Solution

Database Information

CAS : 53847-30-6| Find alternatives

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -80°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H302, H312, H319, H332
P Phrases: P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+310, P302+352, P303+361+353, P304+340, P305+351+338, P312, P321, P330, P337+313, P361+364, P370+378, P403+235, P501
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