2,3-dinor Thromboxane B1

Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2. In rats and rabbits, 2,3-dinor TXB1 has been identified as another urinary metabolite of TXB2. However in human urine, only trace amounts of 2,3-dinor TXB1 have been identified. In rats, 2,3-dinor TXB1 is excreted at a much higher rate than 2,3-dinor TXB2 (19.2 ± 4.9 ng/24 hr and 1.6 ± 0.3 ng/24 hr, respectively). Therefore, urinary 2,3-dinor TXB1 is a suitable marker of thromboxane biosynthesis in rats. Formal Name: 9alpha,11,15S-trihydroxy-2,3-dinor-thromba-13E-en-1-oic acid. CAS Number: 196493-76-2. Synonyms: 2,3-dinor TXB1. Molecular Formula: C18H32O6. Formula Weight: 344.4. Purity: >98%. Formulation: A solution in methyl acetate. Solubility: DMF: 50 mg/ml, DMSO: 20 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): .15 mg/ml. SMILES: O[C@@H]1[C@H](CCCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)OC(O)C1. InChi Code: InChI=1S/C18H32O6/c1-2-3-4-7-13(19)10-11-16-14(8-5-6-9-17(21)22)15(20)12-18(23)24-16/h10-11,13-16,18-20,23H,2-9,12H2,1H3,(H,21,22)/b11-10+/t13-,14-,15-,16+,18?/m0/s1. InChi Key: LGWCOUWMTAQMQT-QCBHMXSDSA-N.