(±)18-HEPE

(±)18-HEPE is produced by non-enzymatic oxidation of eicosapentaenoic acid (EPA, Cay-90110, Cay-90110.1, Cay-21908). 18-HEPE levels are increased in the plasma and heart, as well as in the supernatant of cultured peritoneal macrophages isolated from fat-1 transgenic mice that are capable of endogenously producing omega-3 fatty acids from omega-6 fatty acids. It reduces increases in cardiac fibrosis and the expression of Nppa, Col1a1, Tgfb1, Cx3cl1, and Adgre1 induced by transverse aortic constriction in a mouse model of cardiac hypertrophy when administered at doses of 1 and 5 µg.Formal Name: (±)-18-hydroxy-5Z,8Z,11Z,14Z,16E-eicosapentaenoic acid. CAS Number: 141110-17-0. Molecular Formula: C20H30O3. Formula Weight: 318.5. Purity: >97%. Formulation: (Request formulation change), A solution in ethanol. Solubility: 0.1 M Na2CO3: 2 mg/ml, DMF: Miscible, DMSO: Miscible, Ethanol: Miscible, PBS (pH 7.2): 0.8 mg/ml. lambdamax: 236 nm. SMILES: CCC(O)/C=C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O. InChi Code: InChI=1S/C20H30O3/c1-2-19(21)17-15-13-11-9-7-5-3-4-6-8-10-12-14-16-18-20(22)23/h4-7,10-13,15,17,19,21H,2-3,8-9,14,16,18H2,1H3,(H,22,23)/b6-4-,7-5-,12-10-,13-11-,17-15+. InChi Key: LRWYBGFSVUBWMO-UXNZXXPISA-N.