17(R)-HDHA

Resolvins are a group of polyhydroxylated metabolites of docosahexaenoic acid (DHA) found in the inflammatory exudates of aspirin-treated experimental animals. 17(R)-HDHA is the primary oxygenation product of DHA when exposed to aspirin-inhibited cyclooxygenase-2. 17(R)-HDHA serves as a precursor to resolvins and has intrinsic biological activity, such as the inhibition of TNFalpha-induced IL-1beta expression in human glioma cells.Formal Name: 17R-hydroxy-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid. CAS Number: 155976-53-7. Synonyms: 17(R)-hydroxy Docosahexaenoic Acid, 17(R)-HDoHE. Molecular Formula: C22H32O3. Formula Weight: 344.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: Miscible, DMSO: Miscible, Ethanol: Miscible, PBS (pH 7.2): 0.8 mg/ml. lambdamax: 236 nm. SMILES: CC/C=C\C[C@@H](O)\C=C\C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O. InChi Code: InChI=1S/C22H32O3/c1-2-3-15-18-21(23)19-16-13-11-9-7-5-4-6-8-10-12-14-17-20-22(24)25/h3,5-8,11-16,19,21,23H,2,4,9-10,17-18,20H2,1H3,(H,24,25)/b7-5-,8-6-,13-11-,14-12-,15-3-,19-16+/t21-/m1/s1. InChi Key: SWTYBBUBEPPYCX-NGHKTGSUSA-N.