17-phenyl trinor Prostaglandin F2alpha isopropyl ester

17-phenyl trinor Prostaglandin F2alpha isopropyl ester
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay16824-1 1 mg -

5 - 10 business days*

74.00€
Cay16824-5 5 mg -

5 - 10 business days*

333.00€
Cay16824-10 10 mg -

5 - 10 business days*

590.00€
 
17-phenyl trinor PGF2alpha N-ethyl amide is an F-series prostaglandin analog which has been... more
Product information "17-phenyl trinor Prostaglandin F2alpha isopropyl ester"
17-phenyl trinor PGF2alpha N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost. This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2alpha, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The 17-phenyl trinor PGF2alpha isopropyl ester derivative was examined for IOP-lowering activity during the development of latanoprost. At the dose of 3 µg/eye in the monkey, 17-phenyl trinor PGF2alpha isopropyl ester was the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative was also significantly more irritating to the eye than latanoprost. Formal Name: 9alpha,11alpha,15S-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid, isopropyl ester. CAS Number: 130209-76-6. Synonyms: Bimatoprost isopropyl ester, 17-phenyl trinor PGF2alpha-iPr, 17-phenyl trinor PGF2alpha isopropyl ester. Molecular Formula: C26H38O5. Formula Weight: 430.6. Purity: >98%. Formulation: A solution in ethanol. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 50 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 1 mg/ml. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1. InChi Code: InChI=1S/C26H38O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,16-17,19,21-25,27-29H,4,9,12-15,18H2,1-2H3/b8-3-,17-16+/t21-,22+,23+,24-,25+/m0/s1. InChi Key: JGZRPRSJSQLFBO-FWPUOYPASA-N.
Keywords: 17-phenyl trinor PGF2alpha isopropyl ester, 17-phenyl trinor PGF2alpha-iPr, Bimatoprost isopropyl ester, 9alpha,11alpha,15S-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid, isopropyl ester
Supplier: Cayman Chemical
Supplier-Nr: 16824

Properties

Application: FP receptor agonist
MW: 430.6 D
Formula: C26H38O5
Purity: >98%
Format: Solution

Database Information

CAS : 130209-76-6| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H360
P Phrases: P201, P202, P210, P233, P240, P241, P242, P243, P280, P303+361+353, P308+313, P370+378, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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