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Product information "17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid"
17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARgamma agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 µM). Formal Name: 4Z,7Z,10Z,13Z,15E,19Z-17-oxo-docosapentaenoic acid. CAS Number: 1233715-28-0. Synonyms: EFOX, 17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-DHA, 17-oxo-DHA. Molecular Formula: C22H30O3. Formula Weight: 342.5. Purity: >90%. Formulation: A solution in ethanol. Solubility: DMF: 15 mg/ml, DMSO: 10 mg/ml, Ethanol: 20 mg/ml. lambdamax: 281 nm. SMILES: CC/C=C\CC(=O)/C=C\C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O. InChi Code: InChI=1S/C22H30O3/c1-2-3-15-18-21(23)19-16-13-11-9-7-5-4-6-8-10-12-14-17-20-22(24)25/h3,5-8,11-16,19H,2,4,9-10,17-18,20H2,1H3,(H,24,25)/b7-5-,8-6-,13-11-,14-12-,15-3-,19-16+. InChi Key: QCEBQMMZCFADMF-VIIQGJSXSA-N.