15(S)-Fluprostenol isopropyl ester

15(S)-Fluprostenol isopropyl ester
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay16788-1 1 mg -

3 - 10 business days*

Cay16788-5 5 mg -

3 - 10 business days*

Cay16788-10 10 mg -

3 - 10 business days*

15(S)-Fluprostenol isopropyl ester (15(S)-Flu-Ipr) is the unnatural C-15 epimer of Travoprost.... more
Product information "15(S)-Fluprostenol isopropyl ester"
15(S)-Fluprostenol isopropyl ester (15(S)-Flu-Ipr) is the unnatural C-15 epimer of Travoprost. Travoprost is the Alcon trade name for fluprostenol isopropyl ester, (Flu-Ipr) an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. Flu-Ipr is a prodrug which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid. The free acid, fluprostenol, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. Although data is currently not available for the activity of 15(S)-Flu-Ipr, inversion of the stereochemistry at the 15 position of ocular hypotensive prostaglandins generally lowers the potency approximately 100 fold. Formal Name: 9alpha,11alpha,15S-trihydroxy-16-(3-(trifluoromethyl)phenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, isopropyl ester. CAS Number: 1420791-14-5. Synonyms: 15(S)-Flu-Ipr. Molecular Formula: C26H35F3O6. Formula Weight: 500.6. Purity: >98%. Formulation: A solution in ethanol. Solubility: DMF: 15 mg/ml, DMSO: 12 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 1 mg/ml. lambdamax: 222, 280 nm. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](/C=C/[C@H](O)COC2=CC=CC(C(F)(F)F)=C2)[C@H](O)C1. InChi Code: InChI=1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21+,22+,23-,24+/m0/s1. InChi Key: MKPLKVHSHYCHOC-AURHPGDUSA-N.
Keywords: 15(S)-Flu-Ipr, 9alpha,11alpha,15S-trihydroxy-16-(3-(trifluoromethyl)phenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, isopropyl ester
Supplier: Cayman Chemical
Supplier-Nr: 16788


Application: Bioactive lipid assays
MW: 500.6 D
Formula: C26H35F3O6
Purity: >98%
Format: Solution

Database Information

CAS : 1420791-14-5| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H302, H360
P Phrases: P201, P202, P210, P233, P240, P241, P242, P243, P264, P270, P280, P301+310, P303+361+353, P308+313, P330, P370+378, P403+235, P405, P501
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