15-keto Fluprostenol

15-keto Fluprostenol is a derivative of the FP receptor agonist fluprostenol (Cay-16768) that is oxidized at carbon 15. It is a potential inactive metabolite of 15-keto fluprostenol isopropyl ester (Cay-16786). It is also a potential metabolite of fluprostenol based on the published metabolism of latanoprost (Cay-16812) by 15-hydroxyprostaglandin dehydrogenase in the monkey cornea. 15-keto Fluprostenol is a potential pharmaceutical impurity found in commercial preparations of fluprostenol.Formal Name: (±)15-oxo-9alpha,11alpha-dihydroxy-16,16-(3-(trifluoromethyl)phenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid. Molecular Formula: C23H27F3O6. Formula Weight: 456.5. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 100 mg/ml, DMSO: 100 mg/ml, Ethanol: 100 mg/ml, PBS (pH 7.2): 20 mg/ml. lambdamax: 225 nm. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/C(COC2=CC(C(F)(F)F)=CC=C2)=O)[C@H](O)C1. InChi Code: InChI=1S/C23H27F3O6/c24-23(25,26)15-6-5-7-17(12-15)32-14-16(27)10-11-19-18(20(28)13-21(19)29)8-3-1-2-4-9-22(30)31/h1,3,5-7,10-12,18-21,28-29H,2,4,8-9,13-14H2,(H,30,31)/b3-1-,11-10+/t18-,19-,20+,21-/m1/s1. InChi Key: KWTWHYQJNRDZOJ-XXAASLTGSA-N.