15-keto Fluprostenol

15-keto Fluprostenol
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay16785-1 1 mg -

6 - 10 business days*

62.00€
Cay16785-5 5 mg -

6 - 10 business days*

277.00€
Cay16785-10 10 mg -

6 - 10 business days*

490.00€
 
Fluprostenol is an F-series prostaglandin analog which has been approved for many years as a... more
Product information "15-keto Fluprostenol"
Fluprostenol is an F-series prostaglandin analog which has been approved for many years as a luteolytic in veterinary animals. The isopropyl ester of fluprostenol (travoprost) was recently introduced as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group of fluprostenol produces 15-keto fluprostenol. 15-keto Fluprostenol is a potential metabolite of fluprostenol when administered to animals. 15-keto Fluprostenol is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Products of beta-oxidation account for most of the metabolites of fluprostenol recovered in plasma and urine. However, 15-keto fluprostenol is a minor metabolite, and one which could be enhanced in situations where beta-oxidation is reduced. Formal Name: (±)15-oxo-9alpha,11alpha-dihydroxy-16,16-(3-(trifluoromethyl)phenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid. Molecular Formula: C23H27F3O6. Formula Weight: 456.5. Purity: >98%. Formulation: A solution in methyl acetate. Solubility: DMF: 100 mg/ml, DMSO: 100 mg/ml, Ethanol: 100 mg/ml, PBS (pH 7.2): 20 mg/ml. lambdamax: 225 nm. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/C(COC2=CC(C(F)(F)F)=CC=C2)=O)[C@H](O)C1. InChi Code: InChI=1S/C23H27F3O6/c24-23(25,26)15-6-5-7-17(12-15)32-14-16(27)10-11-19-18(20(28)13-21(19)29)8-3-1-2-4-9-22(30)31/h1,3,5-7,10-12,18-21,28-29H,2,4,8-9,13-14H2,(H,30,31)/b3-1-,11-10+/t18-,19-,20+,21-/m1/s1. InChi Key: KWTWHYQJNRDZOJ-XXAASLTGSA-N.
Keywords: (±)15-oxo-9alpha,11alpha-dihydroxy-16,16-(3-(trifluoromethyl)phenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid
Supplier: Cayman Chemical
Supplier-Nr: 16785

Properties

Application: Bioactive lipid assays
MW: 456.5 D
Formula: C23H27F3O6
Purity: >98%
Format: Solution

Database Information

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: EUH066, H225, H319, H336, H360
P Phrases: , P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P308+313, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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