15-keto-17-phenyl trinor Prostaglandin F2alpha

15-keto-17-phenyl trinor Prostaglandin F2alpha
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay16817-1 1 mg -

6 - 10 business days*

Cay16817-5 5 mg -

6 - 10 business days*

Cay16817-10 10 mg -

6 - 10 business days*

Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular... more
Product information "15-keto-17-phenyl trinor Prostaglandin F2alpha"
Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2alpha. 15-keto-17-phenyl trinor PGF2alpha is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compound, 15-keto PGs still retain the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye. 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2alpha isopropyl ester) is a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 µg/eye. Again, this is not as potent as many other F-type PGs, for example, PGF2alpha will produce this degree of miosis at a dose of less than 1 µg/eye. Formal Name: 9alpha,11alpha-dihydroxy-15-oxo-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid. CAS Number: 949564-89-0. Synonyms: 15-keto-17-phenyl trinor PGF2alpha. Molecular Formula: C23H30O5. Formula Weight: 386.5. Purity: >98%. Formulation: A solution in methyl acetate. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 2.5 mg/ml. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/C(CCC2=CC=CC=C2)=O)[C@H](O)C1. InChi Code: InChI=1S/C23H30O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,14-15,19-22,25-26H,2,7,10-13,16H2,(H,27,28)/b6-1-,15-14+/t19-,20-,21+,22-/m1/s1. InChi Key: HHEYLKRDELKWGI-RKJYIPPQSA-N.
Keywords: 15-keto-17-phenyl trinor PGF2alpha, 9alpha,11alpha-dihydroxy-15-oxo-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid
Supplier: Cayman Chemical
Supplier-Nr: 16817


Application: Bioactive lipid assays
MW: 386.5 D
Formula: C23H30O5
Purity: >98%
Format: Solution

Database Information

CAS : 949564-89-0| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: EUH066, H225, H319, H336, H360
P Phrases: , P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P308+313, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
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