15-deoxy-Delta12,14-Prostaglandin J2-2-glycerol ester

15-deoxy-Delta12,14-Prostaglandin J2-2-glycerol ester
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010132-100 100 µg -

6 - 10 business days*

49.00€
Cay10010132-500 500 µg -

6 - 10 business days*

220.00€
Cay10010132-1 1 mg -

6 - 10 business days*

390.00€
 
15-deoxy-Delta12,14-Prostaglandin J2-2-glycerol ester (15-deoxy-Delta12,14-PGJ2-2-glycerol ester)... more
Product information "15-deoxy-Delta12,14-Prostaglandin J2-2-glycerol ester"
15-deoxy-Delta12,14-Prostaglandin J2-2-glycerol ester (15-deoxy-Delta12,14-PGJ2-2-glycerol ester) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARgamma with an EC50 value of 2 µM in a murine chimera system. 15-deoxy-Delta12,14-PGJ2-2-glycerol ester is more potent than PGD2, Delta12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 value for induction of adipocyte differentiation in cultured fibroblasts is 7 µM. PG glycerol esters are generated by the action of cyclooxygenase-2 on the endocannabinoid 2-arachidonyl glycerol. The biosynthesis of PGH, PGD, PGE, PGF, and TXA-2-glyceryl ester compounds have all been documented. While the stability and metabolism of these PG products has been investigated, little is known about their intrinsic biological activity. Formal Name: 11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oic acid, 2-glycerol ester. Synonyms: 15-deoxy-Delta12,14-PGJ2-2-glycerol ester. Molecular Formula: C23H34O5. Formula Weight: 390.5. Purity: >98% (isomer mixture). Formulation: A solution in ethanol. Solubility: DMF: 25 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 0.3 mg/ml. lambdamax: 229, 306 nm. SMILES: O=C1C=C[C@H](C/C=C\CCCC(OC(CO)CO)=O)/C1=C\C=C\CCCCC. InChi Code: InChI=1S/C23H34O5/c1-2-3-4-5-6-10-13-21-19(15-16-22(21)26)12-9-7-8-11-14-23(27)28-20(17-24)18-25/h6-7,9-10,13,15-16,19-20,24-25H,2-5,8,11-12,14,17-18H2,1H3/b9-7-,10-6+,21-13+/t19-/m0/s1. InChi Key: JGKIBUMNHSZUSL-SLDNAQRASA-N.
Keywords: 15-deoxy-Delta12,14-PGJ2-2-glycerol ester, 11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oic acid, 2-glycerol ester
Supplier: Cayman Chemical
Supplier-Nr: 10010132

Properties

Application: Bioactive lipid assays
MW: 390.5 D
Formula: C23H34O5
Purity: >98% (isomer mixture)
Format: Solution

Database Information

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -80°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H360
P Phrases: P201, P202, P210, P233, P240, P241, P242, P243, P280, P303+361+353, P308+313, P370+378, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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