15-deoxy-Delta12,14-Prostaglandin D2

15-deoxy-Delta12,14-Prostaglandin D2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay12700-500 500 µg -

3 - 10 business days*

99.00€
Cay12700-1 1 mg -

3 - 10 business days*

188.00€
Cay12700-5 5 mg -

3 - 10 business days*

790.00€
 
15-deoxy-Delta12,14-PGD2 is a metabolite of PGD2 (Cay-12010). It is an agonist of PGD2 receptor 2... more
Product information "15-deoxy-Delta12,14-Prostaglandin D2"
15-deoxy-Delta12,14-PGD2 is a metabolite of PGD2 (Cay-12010). It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki = 50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50 = 8 nM). It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor gamma (PPARgamma) and induces PPARgamma-mediated transcription in a reporter assay when used at a concentration of 5 µM. 15-deoxy-Delta12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50 = 0.3 µg/ml). It inhibits ADP-induced platelet aggregation (IC50 = 320 ng/ml) less potently than PGD2. Formal Name: 9alpha-hydroxy-11-oxo-prosta-5Z,12E,14E-trien-1-oic acid. CAS Number: 85235-11-6. Synonyms: 15-deoxy-Delta12,14-PGD2. Molecular Formula: C20H30O4. Formula Weight: 334.5. Purity: >95%. Formulation: A solution in methyl acetate. Solubility: DMF: >100 mg/ml (from PGD2), DMSO: >50 mg/ml (from PGD2), Ethanol: >75 mg/ml (from PGD2), PBS pH 7.2: >5 mg/ml (from PGD2). lambdamax: 296 nm. SMILES: O=C1/C([C@@H](C/C=C\CCCC(O)=O)[C@@H](O)C1)=C/C=C/CCCCC. InChi Code: InChI=1S/C20H30O4/c1-2-3-4-5-6-9-12-16-17(19(22)15-18(16)21)13-10-7-8-11-14-20(23)24/h6-7,9-10,12,17,19,22H,2-5,8,11,13-15H2,1H3,(H,23,24)/b9-6+,10-7-,16-12+/t17-,19+/m1/s1. InChi Key: QUGBPWLPAUHDTI-PLGLXCLHSA-N.
Keywords: 15-deoxy-Delta12,14-PGD2, 9alpha-hydroxy-11-oxo-prosta-5Z,12E,14E-trien-1-oic acid
Supplier: Cayman Chemical
Supplier-Nr: 12700

Properties

Application: Bioactive lipid assays
MW: 334.5 D
Formula: C20H30O4
Purity: >95%
Format: Solution

Database Information

CAS : 85235-11-6| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: EUH066, H225, H319, H336
P Phrases: , P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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