15-deoxy-Delta12,14-Prostaglandin D2

15-deoxy-Delta12,14-PGD2 is a metabolite of PGD2 (Cay-12010). It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki = 50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50 = 8 nM). It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor gamma (PPARgamma) and induces PPARgamma-mediated transcription in a reporter assay when used at a concentration of 5 µM. 15-deoxy-Delta12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50 = 0.3 µg/ml). It inhibits ADP-induced platelet aggregation (IC50 = 320 ng/ml) less potently than PGD2. Formal Name: 9alpha-hydroxy-11-oxo-prosta-5Z,12E,14E-trien-1-oic acid. CAS Number: 85235-11-6. Synonyms: 15-deoxy-Delta12,14-PGD2. Molecular Formula: C20H30O4. Formula Weight: 334.5. Purity: >95%. Formulation: A solution in methyl acetate. Solubility: DMF: >100 mg/ml (from PGD2), DMSO: >50 mg/ml (from PGD2), Ethanol: >75 mg/ml (from PGD2), PBS pH 7.2: >5 mg/ml (from PGD2). lambdamax: 296 nm. SMILES: O=C1/C([C@@H](C/C=C\CCCC(O)=O)[C@@H](O)C1)=C/C=C/CCCCC. InChi Code: InChI=1S/C20H30O4/c1-2-3-4-5-6-9-12-16-17(19(22)15-18(16)21)13-10-7-8-11-14-20(23)24/h6-7,9-10,12,17,19,22H,2-5,8,11,13-15H2,1H3,(H,23,24)/b9-6+,10-7-,16-12+/t17-,19+/m1/s1. InChi Key: QUGBPWLPAUHDTI-PLGLXCLHSA-N.