14,15-Leukotriene E4

14,15-Leukotriene E4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10011362-25 25 µg -

3 - 10 business days*

134.00€
Cay10011362-50 50 µg -

3 - 10 business days*

254.00€
Cay10011362-100 100 µg -

3 - 10 business days*

482.00€
 
Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in... more
Product information "14,15-Leukotriene E4"
Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. These metabolites are classified as eoxins because they are formed mostly by eosinophils. Mast cells and nasal polyps can synthesize 14,15-LTC4 as well, however metabolism to 14,15-LTE4 in these cells and tissue has not been documented. 14,15-LTE4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency than LTC4, but approximately 100-fold greater potency than histamine.
Keywords: 14,15-LTE4, Eoxin E4, EXE4, 15S-hydroxy-14R-(S-cysteinyl)-5Z,8Z,10E,12E-eicosatetraenoic acid
Supplier: Cayman Chemical
Supplier-Nr: 10011362-25

Properties

Application: Bioactive lipid assays
MW: 439.6 D
Formula: C23H37NO5S
Purity: >97%
Format: Solution

Database Information

CAS : 1000852-57-2| Find alternatives

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -80°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H301, H311, H331, H370
P Phrases: P210, P233, P240, P241, P242, P243, P260, P264, P270, P280, P321, P303+P361+P353, P308+P311, P370+P378, P405, P403+P235, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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