14,15-dehydro Leukotriene B4

14,15-dehydro Leukotriene B4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay20150-25 25 µg -

6 - 10 business days*

140.00€
Cay20150-50 50 µg -

6 - 10 business days*

267.00€
Cay20150-100 100 µg -

6 - 10 business days*

504.00€
 
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the... more
Product information "14,15-dehydro Leukotriene B4"
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value of 27 nM, compared to BLT2, which has a Ki value of 473 nM. 14,15-dehydro LTB4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 µM. Formal Name: 5S,12R-dihydroxy-6Z,8E,10E-eicosatrien-14-ynoic acid. CAS Number: 114616-11-4. Synonyms: 14,15-dehydro LTB4. Molecular Formula: C20H30O4. Formula Weight: 334.5. Purity: >97%. Formulation: A solution in ethanol. Solubility: DMF: Miscible, DMSO: Miscible, Ethanol: Miscible, PBS (pH 7.2): >1 mg/ml. SMILES: CCCCCCCC[C@@H](O)/C=C/C=C\C=C\[C@@H](O)CCCC(=O)O. InChi Code: InChI=1S/C20H30O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h7-8,10-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,14-10+,15-11-/t18-,19-/m1/s1. InChi Key: PRCVOEPTHWOJMX-CHHAPGPYSA-N.
Keywords: 14,15-dehydro LTB4, 5S,12R-dihydroxy-6Z,8E,10E-eicosatrien-14-ynoic acid
Supplier: Cayman Chemical
Supplier-Nr: 20150

Properties

Application: LTB4 receptor antagonist
MW: 334.5 D
Formula: C20H30O4
Purity: >97%
Format: Solution

Database Information

CAS : 114616-11-4| Find alternatives

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -80°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225
P Phrases: P210, P233, P240, P241, P242, P243, P280, P303+361+353, P370+378, P403+235, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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