12-oxo Leukotriene B4

12-oxo Leukotriene B4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay20140-10 10 µg -

6 - 10 business days*

Cay20140-25 25 µg -

6 - 10 business days*

Cay20140-50 50 µg -

6 - 10 business days*

Cay20140-100 100 µg -

6 - 10 business days*

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO... more
Product information "12-oxo Leukotriene B4"
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give 10,11-dihydro-LTB4. 12-oxo-LTB4 (EC50 = 33 nM) is about 70-fold less potent than LTB4 (EC50 = 0.46 nM) at stimulating Ca2+ mobilization in human neutrophils. It is also significantly less potent than LTB4 at stimulating neutrophil migration with EC50 values of 170 and 2.7 nM for 12-oxo-LTB4 and LTB4, respectively. Formal Name: 5S-hydroxy-12-oxo-6Z,8E,10E,14Z-eicosatetraenoic acid. CAS Number: 136696-10-1. Synonyms: 12-keto LTB4, 12-oxo LTB4. Molecular Formula: C20H30O4. Formula Weight: 334.4. Purity: >90%. Formulation: A solution in acetonitrile. Solubility: DMF: Miscible, DMSO: Miscible, Ethanol: Miscible, PBS (pH 7.2): > 1 mg/ml. lambdamax: 314 nm. SMILES: CCCCC/C=C\CC(=O)\C=C/C=C\C=C\[C@@H](O)CCCC(=O)O. InChi Code: InChI=1S/C20H30O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,19,22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t19-/m1/s1. InChi Key: SJVWVCVZWMJXOK-NOJHDUNKSA-N.
Keywords: 12-keto LTB4, 12-oxo LTB4, 5S-hydroxy-12-oxo-6Z,8E,10E,14Z-eicosatetraenoic acid
Supplier: Cayman Chemical
Supplier-Nr: 20140


Application: Bioactive lipid assays
MW: 334.4 D
Formula: C20H30O4
Purity: >90%
Format: Solution

Database Information

CAS : 136696-10-1| Find alternatives

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -80°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H312, H319, H332
P Phrases: P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+352, P303+361+353, P304+340, P305+351+338, P312, P321, P337+313, P361+364, P370+378, P403+235, P501
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