(±)12(13)-DiHOME-d4

(±)12(13)-DiHOME-d4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10009994-25 25 µg -

6 - 10 business days*

94.00€
Cay10009994-50 50 µg -

6 - 10 business days*

179.00€
Cay10009994-100 100 µg -

6 - 10 business days*

338.00€
Cay10009994-250 250 µg -

6 - 10 business days*

750.00€
 
(±)12(13)-DiHOME-d4 is intended for use as an internal standard for the quantification of... more
Product information "(±)12(13)-DiHOME-d4"
(±)12(13)-DiHOME-d4 is intended for use as an internal standard for the quantification of (±)12(13)-DiHOME (Cay-10009832) by GC- or LC-MS. (±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME, a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin. It is formed from 12(13)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils. 12(13)-DiHOME is toxic to Sf21 cells expressing sEH and to lacZ-expressing control cells, unlike isoleukotoxin, which is only toxic to cells containing sEH. Levels of 12(13)-DiHOME are increased in rat spinal cord following burn injury, and it enhances cold tolerance, increases fatty acid uptake into brown adipocytes, and decreases serum triglyceride levels in mice. Levels are also elevated in bronchoalveolar lavage fluid (BALF) in humans following exposure to biodiesel exhaust and in exhaled breath condensate in patients with asthma following allergen exposure. Plasma levels of 12(13)-DiHOME are increased immediately following moderate-intensity exercise in mice and humans, an effect that can be prevented by brown adipose tissue removal in the mouse. Formal Name: (±)12,13-dihydroxy-9Z-octadecenoic-9,10,12,13-d4 acid. Synonyms: Isoleukotoxin diol-d4. Molecular Formula: C18H30D4O4. Formula Weight: 318.5. Purity: >99% deuterated forms (d1-d4). Formulation: A solution in methyl acetate. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 10 µg/ml. SMILES: CCCCC[C@](O)([2H])[C@](O)([2H])C/C([2H])=C([2H])\CCCCCCCC(O)=O. InChi Code: InChI=1S/C18H34O4/c1-2-3-10-13-16(19)17(20)14-11-8-6-4-5-7-9-12-15-18(21)22/h8,11,16-17,19-20H,2-7,9-10,12-15H2,1H3,(H,21,22)/b11-8-/t16-,17+/m1/s1/i8D,11D,16D,17D. InChi Key: CQSLTKIXAJTQGA-FIMKFYBQSA-N.
Keywords: Isoleukotoxin diol-d4, (±)12,13-dihydroxy-9Z-octadecenoic-9,10,12,13-d4 acid
Supplier: Cayman Chemical
Supplier-Nr: 10009994

Properties

Application: Bioactive lipid assays
MW: 318.5 D
Formula: C18H30D4O4
Purity: >99% deuterated forms (d1-d4)
Format: Solution

Database Information

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: EUH066, H225, H319, H336
P Phrases: , P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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