11-keto Fluprostenol

11-keto Fluprostenol is an analog of prostaglandin D2 (PGD2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2alpha and acts primarily through the FP receptor. Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP2 receptor compared to PGD2 and essentially no activity at the DP1 receptor.Formal Name: 7-[(1R,2R,5S)-5Z-hydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-3-oxocyclopentyl]-5-heptenoic acid. CAS Number: 62145-07-7. Synonyms: Fluprostenol Prostaglandin D2. Molecular Formula: C23H27F3O6. Formula Weight: 456.5. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: PBS (7.2): 29 mg/ml. lambdamax: 221, 276 nm. SMILES: O[C@@H](C1)[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)COC2=CC=CC(C(F)(F)F)=C2)C1=O. InChi Code: InChI=1S/C23H27F3O6/c24-23(25,26)15-6-5-7-17(12-15)32-14-16(27)10-11-19-18(20(28)13-21(19)29)8-3-1-2-4-9-22(30)31/h1,3,5-7,10-12,16,18-20,27-28H,2,4,8-9,13-14H2,(H,30,31)/b3-1-,11-10+/t16-,18-,19-,20+/m1/s1. InChi Key: MDMHJAKZGBRYTF-KYUUVOLFSA-N.